{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:18:44Z","timestamp":1765887524439},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T00:00:00Z","timestamp":1375142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Background<\/jats:title>A considerable number of patients with atrial fibrillation (AF<\/jats:styled-content>) develop cardioembolic stroke (CE<\/jats:styled-content>) despite low CHADS<\/jats:styled-content>2<\/jats:sub> score. We examined the possibility that use of the atrial electromechanical interval (AEMI<\/jats:styled-content>) improves prediction of CE<\/jats:styled-content> in patients with paroxysmal AF<\/jats:styled-content> (PAF<\/jats:styled-content>), particularly those with low CHADS<\/jats:styled-content>2<\/jats:sub> score.<\/jats:p><\/jats:sec>Methods<\/jats:title>We consecutively enrolled 108 patients with nonvalvular PAF<\/jats:styled-content> and 52 healthy subjects as controls. The PAF<\/jats:styled-content> patients were divided into 2 groups depending on presence (n\u00a0=\u00a036) or absence (n\u00a0=\u00a072) of the history of CE<\/jats:styled-content>. Left atrial (LA<\/jats:styled-content>) volume index (LAVI<\/jats:styled-content>), peak myocardial velocity during late diastole (a'), and AEMI<\/jats:styled-content> as time from onset of P\u2010wave to onset of lateral a' were measured.<\/jats:p><\/jats:sec>Results<\/jats:title>Patients with PAF<\/jats:styled-content> had significantly larger LAVI<\/jats:styled-content>, longer AEMI<\/jats:styled-content>, and lower lateral a' than those in controls. Area under the curves for LAVI<\/jats:styled-content>, lateral a', and AEMI<\/jats:styled-content> for identifying patients with PAF<\/jats:styled-content> were 0.70, 0.69, and 0.88, respectively. Multivariate logistic regression analysis indicated that age, use of antiarrhythmic drugs, and AEMI<\/jats:styled-content>, but not LAVI<\/jats:styled-content> or a', were independently associated with history of CE<\/jats:styled-content> in patients with PAF<\/jats:styled-content>. PAF<\/jats:styled-content> patients were categorized into low risk by CHADS<\/jats:styled-content>2<\/jats:sub> score (i.e. CHADS<\/jats:styled-content>2<\/jats:sub> score\u00a0=\u00a00 or 1, n\u00a0=\u00a060), those with prolonged AEMI<\/jats:styled-content> (>82\u00a0msec) had significantly higher rates of CE<\/jats:styled-content> than those with \u226482\u00a0msec (48% vs. 15%, P\u00a0<\u00a00.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>As compared with echocardiographic parameters of LA<\/jats:styled-content> size and LA<\/jats:styled-content> function, AEMI<\/jats:styled-content> appears to be more useful for identifying PAF<\/jats:styled-content> patients. AEMI<\/jats:styled-content> may enable to detect high risk PAF<\/jats:styled-content> patients, especially those categorized into low risk by CHADS<\/jats:styled-content>2<\/jats:sub> score.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12329","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T06:54:06Z","timestamp":1375167246000},"page":"140-148","source":"Crossref","is-referenced-by-count":9,"title":["Atrial Electromechanical Interval May Predict Cardioembolic Stroke in Apparently Low Risk Elderly Patients with Paroxysmal Atrial Fibrillation"],"prefix":"10.1111","volume":"31","author":[{"given":"Yoko","family":"Hoshi","sequence":"first","affiliation":[{"name":"Division of Laboratory Diagnosis Japanese Red Cross Asahikawa Hospital Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukinaga","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Asahikawa Hospital 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