{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:18:13Z","timestamp":1793258293104,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Functional mitral regurgitation (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) can occur secondary to severe aortic regurgitation (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>). However, data on the overall impact of mitral surgical intervention after aortic valve replacement (<jats:styled-content style=\"fixed-case\">AVR<\/jats:styled-content>) are scarce. We sought to study the left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) remodeling process and determine predictors of clinical outcomes of patients with pure severe <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> in presence or absence of significant functional <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were categorized into <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> group (\u2264 mild <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>; n\u00a0=\u00a051, 76%) and <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> group (\u2265 moderate <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>; n\u00a0=\u00a016, 24%). All patients in the <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> group underwent <jats:styled-content style=\"fixed-case\">AVR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> correction. Serial echocardiographic measurements and clinical follow\u2010up up to 5\u00a0years were obtained in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant reverse LV remodeling occurred in both groups compared with baseline. No 30\u2010day deaths occurred. Mortality and heart failure\u2010related hospitalization rates, at follow\u2010up, were significantly higher in the AR\u00a0+\u00a0MR group (19% vs. 2%, P\u00a0=\u00a00.04 and 38% vs. 12% P\u00a0=\u00a00.03, respectively), but a similar proportion of patients from both groups was in New York Heart Association class I or II (87% vs. 92%, P\u00a0=\u00a00.62). Preoperative indexed stroke volume (SV) &lt;50\u00a0mL\/m<jats:sup>2<\/jats:sup> was the only independent predictor of death and\/or rehospitalization after surgery (odds ratio: 61.1, [95% CI, 12.6\u2013425.2]; P\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite being a higher risk population, patients with moderate\u2010to\u2010severe functional MR secondary to severe AR experience similar postoperative mortality at the expense of a moderately higher 5\u2010year overall mortality, rate of hospitalization for congestive heart failure, and medication use. Preoperative indexed SV\u00a0&lt;\u00a050\u00a0mL\/m<jats:sup>2<\/jats:sup> may be helpful in predicting long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12450","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T06:40:55Z","timestamp":1385448055000},"page":"689-698","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes Following Surgical Correction of Pure Aortic Regurgitation in Presence or Absence of Significant Functional Mitral Regurgitation"],"prefix":"10.1111","volume":"31","author":[{"given":"Jimmy","family":"MacHaalany","sequence":"first","affiliation":[{"name":"Department of Cardiology Quebec Heart and Lung Institute Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier F.","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Department of Cardiology Quebec Heart and Lung Institute Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Voisine","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Quebec Heart and Lung Institute Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Cardiology Quebec Heart and Lung Institute Quebec City Quebec Canada"},{"name":"Research Center Quebec Heart and Lung Institute Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Bernier","sequence":"additional","affiliation":[{"name":"Department of Cardiology Quebec Heart and Lung Institute Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaie\u2010Nicolas","family":"Dubois\u2010S\u00e9n\u00e9chal","sequence":"additional","affiliation":[{"name":"Research Center Quebec Heart and Lung Institute Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Olivier","family":"Jacques","sequence":"additional","affiliation":[{"name":"Research Center Quebec Heart and Lung Institute Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Viel","sequence":"additional","affiliation":[{"name":"Research Center Quebec Heart and Lung Institute Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Dubois","sequence":"additional","affiliation":[{"name":"Research Center Quebec Heart and Lung Institute Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"S\u00e9n\u00e9chal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Quebec Heart and Lung Institute Quebec City Quebec 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