{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:57:44Z","timestamp":1696334264352},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,12,28]],"date-time":"2013-12-28T00:00:00Z","timestamp":1388188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical relevance of examining human atrial natriuretic peptide (<jats:styled-content style=\"fixed-case\">HANP<\/jats:styled-content>) or left atrial appendage (<jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content>) wall\u2010motion velocity during sinus rhythm in paroxysmal atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) patients has not been clearly elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects were 38 patients with paroxysmal <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> who underwent transesophageal and transthoracic echocardiography during sinus rhythm. The presence of spontaneous echocontrast (<jats:styled-content style=\"fixed-case\">SEC<\/jats:styled-content>) was examined with transesophageal echocardiography and <jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content> wall\u2010motion velocity (<jats:styled-content style=\"fixed-case\">LAAWV<\/jats:styled-content>) was measured with transthoracic tissue Doppler echocardiography. Plasma <jats:styled-content style=\"fixed-case\">HANP<\/jats:styled-content> was measured within 3\u00a0hours after echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Human atrial natriuretic peptide ranged from 12 to 106\u00a0pg\/mL with an average of 43\u00a0\u00b1\u00a024\u00a0pg\/mL and had a significant correlation with LAAWV (r\u00a0=\u00a0\u22120.57) or LAA flow velocity (r\u00a0=\u00a0\u22120.41). HANP was significantly higher in patients with SEC than in patients without SEC (64\u00a0\u00b1\u00a029 vs. 34\u00a0\u00b1\u00a015\u00a0pg\/mL, P\u00a0=\u00a00.008) and LAAWV was significantly lower in patients with SEC than in patients without SEC (13\u00a0\u00b1\u00a05 vs. 20\u00a0\u00b1\u00a05\u00a0cm\/sec, P\u00a0=\u00a00.002). HANP &gt;44\u00a0pg\/mL had a sensitivity of 73% and specificity of 89% for diagnosing SEC. SEC was more frequently observed (73%) in patients with HANP &gt;44\u00a0pg\/mL and\/or LAAWV &lt;10\u00a0cm\/sec as compared with patients (11%) with normal HANP and LAA wall\u2010motion velocity (P\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher plasma <jats:styled-content style=\"fixed-case\">HANP<\/jats:styled-content> and lower <jats:styled-content style=\"fixed-case\">LAA<\/jats:styled-content> wall\u2010motion velocity may be noninvasive surrogate markers for assessing left atrial thrombogenesis during sinus rhythm in paroxysmal <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12501","type":"journal-article","created":{"date-parts":[[2013,12,28]],"date-time":"2013-12-28T07:56:42Z","timestamp":1388217402000},"page":"965-971","source":"Crossref","is-referenced-by-count":7,"title":["High Plasma Human Atrial Natriuretic Peptide and Reduced Transthoracic Left Atrial Appendage Wall\u2010Motion Velocity Are Noninvasive Surrogate Markers for Assessing Thrombogenesis in Patients with Paroxysmal Atrial Fibrillation"],"prefix":"10.1111","volume":"31","author":[{"given":"Naoyasu","family":"Yoshida","sequence":"first","affiliation":[{"name":"Echocardiography Division Department of Laboratory Medicine Hiroshima Prefectural Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsunori","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hiroshima Prefectural Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Hirao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hiroshima Prefectural Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Suenari","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hiroshima Prefectural Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyomi","family":"Nanba","sequence":"additional","affiliation":[{"name":"Echocardiography Division Department of Laboratory Medicine Hiroshima Prefectural Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mio","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hiroshima Prefectural Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Yamazato","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hiroshima Prefectural Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Watari","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hiroshima Prefectural Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hiroshima Prefectural Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hiroshima Prefectural Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"46","article-title":"Atrial stretch increases sodium excretion independently of release of atrial peptides","volume":"50","author":"Goetz KL","year":"1986","journal-title":"Am J 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