{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:38:41Z","timestamp":1790829521049,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T00:00:00Z","timestamp":1392336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Background<\/jats:title>The role of inflammation in fibrotic and calcific processes of atherosclerosis and aortic stenosis (AS<\/jats:styled-content>) is similar. Furthermore, a relationship between systemic inflammation and heart failure has been well demonstrated. Recently, neutrophil\/lymphocyte ratio (NLR<\/jats:styled-content>) has been proposed as a predictive marker of systemic inflammation. We investigated the association of NLR<\/jats:styled-content> with the severity of calcific AS<\/jats:styled-content> and left ventricular (LV<\/jats:styled-content>) systolic dysfunction in patients with severe calcific AS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 96 patients with calcific AS<\/jats:styled-content> were included in this retrospective study from 2011 to 2013. The severity of AS<\/jats:styled-content> was graded according to the transaortic mean pressure gradient. The patients were divided into 3 groups as mild\u2010to\u2010moderate AS<\/jats:styled-content>, severe AS<\/jats:styled-content> with normal left ventricular ejection fraction (LVEF<\/jats:styled-content>), and severe AS<\/jats:styled-content> with reduced LVEF<\/jats:styled-content> (mean gradient >40\u00a0mmHg and LVEF<\/jats:styled-content> <50%).<\/jats:p><\/jats:sec>Results<\/jats:title>Neutrophil\/lymphocyte ratio was significantly higher in severe calcific AS<\/jats:styled-content> with reduced LVEF<\/jats:styled-content> group than the other 2 groups (3.94\u00a0\u00b1\u00a00.88, P\u00a0<\u00a00.001). In addition, NLR<\/jats:styled-content> was higher in severe AS<\/jats:styled-content> with normal LVEF<\/jats:styled-content> group than mild\u2010to\u2010moderate AS<\/jats:styled-content> group (2.69\u00a0\u00b1\u00a01.00 vs. 2.05\u00a0\u00b1\u00a00.64, P\u00a0=\u00a00.008). There was a statistically significant correlation between NLR<\/jats:styled-content> and both transaortic mean pressure gradient and aortic valve peak velocity in patients with mild\u2010to\u2010severe AS<\/jats:styled-content> with normal LVEF<\/jats:styled-content> (n\u00a0=\u00a081; r\u00a0=\u00a00.369, P\u00a0<\u00a00.001; r\u00a0=\u00a00.290, P\u00a0=\u00a00.004; respectively).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Increased NLR<\/jats:styled-content> is related to the severity of calcific AS<\/jats:styled-content> and LV<\/jats:styled-content> systolic dysfunction in patients with severe calcific AS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12534","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T05:21:28Z","timestamp":1392614488000},"page":"1031-1035","source":"Crossref","is-referenced-by-count":40,"title":["The Relationship between Neutrophil\/Lymphocyte Ratio and Calcific Aortic Stenosis"],"prefix":"10.1111","volume":"31","author":[{"given":"Anil","family":"Avci","sequence":"first","affiliation":[{"name":"Cardiology Deparment Kartal Ko\u015fuyolu Heart Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alizade","family":"Elnur","sequence":"additional","affiliation":[{"name":"Cardiology Deparment Kartal Ko\u015fuyolu Heart Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Acar","family":"G\u00f6ksel","sequence":"additional","affiliation":[{"name":"Cardiology Deparment Kartal Ko\u015fuyolu Heart Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fidan","family":"Serdar","sequence":"additional","affiliation":[{"name":"Cardiology Deparment Kartal Ko\u015fuyolu Heart Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izci","family":"Servet","sequence":"additional","affiliation":[{"name":"Cardiology Deparment Kartal Ko\u015fuyolu Heart Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koyuncu","family":"Atilla","sequence":"additional","affiliation":[{"name":"Cardiology Deparment Kartal Ko\u015fuyolu Heart Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabakc\u0131 Mehmet","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Cardiology Deparment Kartal Ko\u015fuyolu Heart Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toprak","family":"Cuneyt","sequence":"additional","affiliation":[{"name":"Cardiology Deparment Kartal Ko\u015fuyolu Heart Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guler","family":"Yeliz","sequence":"additional","affiliation":[{"name":"Cardiology Deparment Kartal Ko\u015fuyolu Heart Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulut","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Cardiology Deparment Kartal Ko\u015fuyolu Heart Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esen Ali","family":"Metin","sequence":"additional","affiliation":[{"name":"Cardiology Deparment Kartal Ko\u015fuyolu Heart Research and Training Hospital Istanbul 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