{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:11:23Z","timestamp":1695618683824},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T00:00:00Z","timestamp":1391817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>In this study, we aimed to elucidate the factors affecting long\u2010term all\u2010cause mortality in patients with hypertrophic cardiomyopathy (<jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively examined 31 patients (22 males and 9 females) diagnosed with <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content> from 1999 to 2013. All subjects had sinus rhythm at the time of evaluation. Four patients had history of paroxysmal atrial fibrillation (<jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content>). In addition to echocardiographic examination plasma angiotensin\u2010converting enzyme (<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>) activity and gene polymorphism were determined. The variables that were found to be significant in mortality were then included in multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the final follow\u2010up examination, 12 patients had died, including 2 due to congestive heart failure and 10 due to sudden cardiac death. Patients with <jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content> had significantly higher mortality (P\u00a0=\u00a00.008). Moreover, left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) end\u2010diastolic diameter (P\u00a0=\u00a00.04), <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> systolic diameter (P\u00a0=\u00a00.001), <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> mass index (P\u00a0=\u00a00.01), and left atrium diameter (P\u00a0=\u00a00.003) were found to be significantly correlated with mortality. However, no significant correlation was noted between mortality and age, type of <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content> (familial\/nonfamilial and obstructive\/nonobstructive), <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> gene polymorphism, and plasma <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> level. In the multivariate analysis, left atrial (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>) diameter was still significantly associated with mortality. The <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> diameter with a cutoff value of 4.1\u00a0cm predicted 13\u2010year mortality with a sensitivity of 82% and specificity of 78%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Instead of the <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> genotype and activity, echocardiographic evaluation findings such as <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> systolic and diastolic diameters, <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> mass index, and particularly <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> dimension may predict long\u2010term mortality in patients with <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>. PAF has also significant importance in the long\u2010term mortality in patients with <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12537","type":"journal-article","created":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T12:21:30Z","timestamp":1391862090000},"page":"1056-1061","source":"Crossref","is-referenced-by-count":4,"title":["Factors Predicting Long\u2010Term Mortality in Patients with Hypertrophic Cardiomyopathy"],"prefix":"10.1111","volume":"31","author":[{"given":"Cem","family":"Bostan","sequence":"first","affiliation":[{"name":"Department of Cardiology Institute of Cardiology Istanbul University Haseki Istanbul\/Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umit Yasar","family":"Sinan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute of Cardiology Istanbul University Haseki Istanbul\/Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polat","family":"Canbolat","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute of Cardiology Istanbul University Haseki Istanbul\/Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Okay","family":"Abaci","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute of Cardiology Istanbul University Haseki Istanbul\/Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sezer Karcier","family":"Munipoglu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute of Cardiology Istanbul University Haseki Istanbul\/Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Kucukoglu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute of Cardiology Istanbul University Haseki Istanbul\/Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep157"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.6.1816"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114844"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92064-Z"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.841"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.62.2.212"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq108"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025050"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2013.10.011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.095232"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04005-8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02713-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.7.650"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)92820-R"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006153422403"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021332"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl041"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.12.067"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.079"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.001"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90151-1"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-9-34"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.05.013"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e328356a231"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes200"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.6.1387"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2009005000001"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.05.003"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604183341604"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.12537","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.12537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:56:15Z","timestamp":1695563775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.12537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,8]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/echo.12537"],"URL":"https:\/\/doi.org\/10.1111\/echo.12537","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,8]]}}}