{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:28:40Z","timestamp":1761863320816},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of long\u2010acting calcium channel blocker (<jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>) administration on serial changes in left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) function and morphology in hypertensive patients with <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> hypertrophy remains unclear. This study attempted to clarify this impact by comparing the effects of administration of azelnidipine with that of amlodipine using conventional and speckle tracking echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An equal number (16) of 32 hypertensive patients was prospectively assigned to a group administered 5\u00a0mg of amlodipine\/day or a group administered 16\u00a0mg of azelnidipine\/day. <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> function and morphology was examined by conventional and speckle tracking echocardiography at baseline and at 1, 3, 6, and 12\u00a0months after treatment initiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups were found to have experienced a significant decrease in systolic blood pressure by 1\u00a0month after treatment initiation; a significant reduction in septal thickness and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> mass index at 6 and 12\u00a0months. Transmitral flow E\/A ratio and early diastolic mitral annular velocity at lateral wall significantly improved at 12\u00a0months. On the other hand, a significant improvement of global longitudinal strain was observed earlier than the above indexes at 3, 6, and 12\u00a0months. Ar\u2010A duration difference was significantly decreased at 3\u00a0months. The global circumferential strain improved significantly at 3\u00a0months, but there were no significant changes in mid\u2010\/apical circumferential and radial strains throughout the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Azelnidipine has beneficial effects on <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> mass regression, transmitral flow, tissue Doppler, and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> longitudinal strain that are comparable to those of amlodipine on the same parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12548","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T05:53:29Z","timestamp":1395294809000},"page":"1230-1238","source":"Crossref","is-referenced-by-count":23,"title":["Impact of Azelnidipine and Amlodipine on Left Ventricular Mass and Longitudinal Function in Hypertensive Patients with Left Ventricular 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