{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:08:31Z","timestamp":1760249311944},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Left ventricular hypertrophy (<jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>) develops as a result of several clinical conditions, such as intensive training, hypertension, aortic valve stenosis. Aim of this study was to analyze the left ventricular twist (<jats:styled-content style=\"fixed-case\">LVT<\/jats:styled-content>) modifications in <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content> patients with increasing after\u2010load conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 131 patients were enrolled: 17 healthy sedentary people (Hg), without concentric <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>; 45 water polo players (<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>g); 22 patients with hypertensive cardiopathy (<jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>g); 47 patients with different degrees of aortic stenosis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>g); all patients had concentric <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>, ejection fraction (<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>) &gt;54%, and were age\u2010matched. The left ventricular end\u2010systolic wall stress (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ESWS<\/jats:styled-content>) was used as index of after\u2010load.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Left ventricular twist value showed a progressive increase from <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>g to <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>g, according to increasing after\u2010load. Longitudinal left ventricular function by tissue Doppler imaging (<jats:styled-content style=\"fixed-case\">TDI<\/jats:styled-content>) and speckle tracking echocardiography (<jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>) was reduced in <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>g and <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>g. There was a negative correlation between <jats:styled-content style=\"fixed-case\">LVT<\/jats:styled-content> and longitudinal systolic function at <jats:styled-content style=\"fixed-case\">TDI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> (r\u00a0=\u00a0\u22120.4; P\u00a0&lt;\u00a00.001; \u22120.23; P\u00a0&lt;\u00a00.05). E\/A ratio was lower in <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>g and <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>g than <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>g and Hg. <jats:styled-content style=\"fixed-case\">LVT<\/jats:styled-content> was linearly related to <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ESWS<\/jats:styled-content> (r\u00a0=\u00a00.36; P\u00a0&lt;\u00a00.01), E\/A ratio (r\u00a0=\u00a0\u20100.59; P\u00a0&lt;\u00a00.001), E\/E\u2032 ratio (r\u00a0=\u00a00.43; P\u00a0&lt;\u00a00.001), age (r\u00a0=\u00a00.5; P\u00a0&lt;\u00a00.001), relative wall thickness (<jats:styled-content style=\"fixed-case\">RWT<\/jats:styled-content>) (r\u00a0=\u00a00.38; P\u00a0&lt;\u00a00.01), heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) (r\u00a0=\u00a00.3; P\u00a0&lt;\u00a00.05), maximum (G. max), and mean transvalvular gradient (G. mean) in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>g (r\u00a0=\u00a00.37; P\u00a0&lt;\u00a00.01, r\u00a0=\u00a00.4; P\u00a0&lt;\u00a00.01). <jats:styled-content style=\"fixed-case\">RWT<\/jats:styled-content>, E\/A ratio, and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> were independent predictor of <jats:styled-content style=\"fixed-case\">LVT<\/jats:styled-content> (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.23; P\u00a0=\u00a00.007; \u22120.44; P\u00a0=\u00a00.001; 0.17; P\u00a0=\u00a00.049). Only in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>g, G. mean was independent predictor of <jats:styled-content style=\"fixed-case\">LVT<\/jats:styled-content> (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.44; P\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Left ventricular twist showed a linear trend at increasing after\u2010load values to compensate the reduction in systolic longitudinal function in pathological <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12555","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T11:45:13Z","timestamp":1395315913000},"page":"1265-1273","source":"Crossref","is-referenced-by-count":18,"title":["Left Ventricular Twisting Modifications in Patients with Left Ventricular Concentric Hypertrophy at Increasing After\u2010Load 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