{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:48:58Z","timestamp":1777621738411,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Early detection of right ventricular (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) and left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) dysfunction in patients with repaired tetralogy of Fallot (<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>) is essential because dysfunction is correlated with a poor clinical outcome. The aim of this study was to assess <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> function in asymptomatic children with repaired <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> by two\u2010dimensional ultrasound speckle tracking echocardiography (<jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010six asymptomatic children with a preserved biventricular ejection fraction (<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>) after repair of <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> and 35 healthy control subjects were studied. <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> strain and strain rate were measured by <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">RVEF<\/jats:styled-content> and pulmonary regurgitation (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>) were assessed using cardiac magnetic resonance imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the control subjects, <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> regional longitudinal strain and strain rate and global longitudinal strain (<jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>) and strain rate (<jats:styled-content style=\"fixed-case\">GLSR<\/jats:styled-content>) were impaired in children with repaired <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>. Likewise, <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> circumferential and radial strain and strain rate were reduced in patients with <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>. In contrast, longitudinal strain and strain rate did not differ between the groups. <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LV GLSR<\/jats:styled-content> were correlated with postoperative follow\u2010up period (r<jats:sub>1<\/jats:sub>\u00a0=\u00a0\u22120.44; r<jats:sub>2<\/jats:sub>\u00a0=\u00a0\u22120.48). <jats:styled-content style=\"fixed-case\">RV GLS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GLSR<\/jats:styled-content> were associated with <jats:styled-content style=\"fixed-case\">RVEF<\/jats:styled-content> (r<jats:sub>1<\/jats:sub>\u00a0=\u00a00.64; r<jats:sub>2<\/jats:sub>\u00a0=\u00a00.60) and <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> (r<jats:sub>1<\/jats:sub>\u00a0=\u00a0\u22120.48; r<jats:sub>2<\/jats:sub>\u00a0=\u00a0\u22120.49). <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> circumferential strain rate was related to <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> (r\u00a0=\u00a0\u22120.45).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> can identify abnormalities that may represent early impairment of <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> systolic function in postoperative <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> patients with a preserved <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> is associated with decreased biventricular performance in repaired patients. <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>\u2010derived strain and strain rate may be useful indices for detecting the early deterioration of biventricular performance in patients with <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12581","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T06:52:55Z","timestamp":1395730375000},"page":"135-143","source":"Crossref","is-referenced-by-count":46,"title":["Impaired Right and Left Ventricular Function in Asymptomatic Children with Repaired Tetralogy of Fallot by Two\u2010Dimensional Speckle Tracking Echocardiography Study"],"prefix":"10.1111","volume":"32","author":[{"given":"Yuman","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasonography Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinfang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingping","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002033420507"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02714-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.10.045"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.086983"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2011.01588.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2012.01738.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2012.01808.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2011.01617.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12131"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2011.01434.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2342-13-6"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-009-9477-7"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2003.04.033"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02435-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.05.018"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02566-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.18.2.209"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.548727"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.01.014"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2011.01417.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.06.043"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.02.011"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.06.022"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep209"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.08.008"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138397.60956.c2"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.12581","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.12581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:40:26Z","timestamp":1695570026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.12581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,25]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/echo.12581"],"URL":"https:\/\/doi.org\/10.1111\/echo.12581","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,25]]}}}