{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T22:35:03Z","timestamp":1774650903688,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Guangxi Department of education","award":["2013LX034"],"award-info":[{"award-number":["2013LX034"]}]},{"name":"Guangxi Health Ministry (Medicine)","award":["Z2011363"],"award-info":[{"award-number":["Z2011363"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study evaluated the feasibility of assessing left atrium (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>) function and asynchrony in patients with rheumatic mitral stenosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) before and immediately after percutaneous balloon mitral valvuloplasty (<jats:styled-content style=\"fixed-case\">PBMV<\/jats:styled-content>) by real time three\u2010dimensional echocardiography (RT3DE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty patients with rheumatic <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> who underwent <jats:styled-content style=\"fixed-case\">PBMV<\/jats:styled-content> and 30 controls were enrolled. RT3DE was used to measure <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> volume and function, the standard deviation of time to the minimal systolic volume divided into 16 segments, 12 segments, or 6 segments (Tmsv 16\u2010<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>, Tmsv 12\u2010<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>, Tmsv 6\u2010<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>), and the maximum differences (Tmsv 16\u2010Dif, 12\u2010Dif, 6\u2010Dif) in RT3DE derived values in <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients before and 2\u00a0days after <jats:styled-content style=\"fixed-case\">PBMV<\/jats:styled-content> were obtained and compared with those of normal controls. The associations between the <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> asynchrony and heart volume, function, mitral valve area (<jats:styled-content style=\"fixed-case\">MVA<\/jats:styled-content>), maximum mitral valve gradient (MVG<jats:sub>max<\/jats:sub>), mean mitral valve gradient (<jats:styled-content style=\"fixed-case\">MVG<\/jats:styled-content>mean), and mean <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> pressure (<jats:styled-content style=\"fixed-case\">MLAP<\/jats:styled-content>) were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Left atrium asynchrony indexes were significantly larger, and <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> function parameters were significantly lower in the <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> group than in the controls (P\u00a0&lt;\u00a00.05 for all). Of all the <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> asynchrony indexes, <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> Tmsv16\u2010<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> was most significantly correlated with the <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> volume and function parameters, <jats:styled-content style=\"fixed-case\">MVG<\/jats:styled-content><jats:sub>max<\/jats:sub>, <jats:styled-content style=\"fixed-case\">MVG<\/jats:styled-content><jats:sub>mean<\/jats:sub>, and <jats:styled-content style=\"fixed-case\">MLAP<\/jats:styled-content> (P\u00a0&lt;\u00a00.05 for all). <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> asynchrony indexes and <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> volume significantly deceased, and <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> function significantly increased post\u2010<jats:styled-content style=\"fixed-case\">PBMV<\/jats:styled-content> (P\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Real time three\u2010dimensional echocardiography is a reliable and reproducible method to quantify <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> function and asynchrony. RT3DE revealed a significant, early improvement in <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> function and asynchrony in <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients after <jats:styled-content style=\"fixed-case\">PBMV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12645","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T14:06:39Z","timestamp":1402668399000},"page":"291-301","source":"Crossref","is-referenced-by-count":10,"title":["Left Atrial Asynchrony and Mechanical Function in Patients with Mitral Stenosis before and Immediately after Percutaneous Balloon Mitral Valvuloplasty: A Real Time Three\u2010Dimensional Echocardiography Study"],"prefix":"10.1111","volume":"32","author":[{"given":"Yan","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Guangxi Medical University Nanning 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