{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:11:14Z","timestamp":1695618674503},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T00:00:00Z","timestamp":1406160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>A 48\u2010year\u2010old male with history of chronic arthritis and uveitis presented with 1\u00a0year of progressively reduced exercise capacity and nonexertional chest pain. Physical examination was consistent with severe aortic insufficiency. An electrocardiogram demonstrated sinus rhythm with first degree atrioventricular block. Transthoracic and transesophageal echocardiography demonstrated severe lone central aortic insufficiency of a trileaflet valve due to leaflet thickening, retraction of leaflet margins and mild aortic root dilation in the setting of left ventricular dilatation. In addition, computed tomographic angiography revealed a small focal aneurysm of the distal transverse arch. He was found to be positive for the immunogenetic marker <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B27. The patient subsequently underwent uncomplicated mechanical aortic valve replacement. The diagnosis of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B27 associated cardiac disease should be entertained in any individual with lone aortic insufficiency, especially if accompanied by conduction disease.<\/jats:p>","DOI":"10.1111\/echo.12691","type":"journal-article","created":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T12:39:43Z","timestamp":1406205583000},"source":"Crossref","is-referenced-by-count":1,"title":["Lone Aortic Insufficiency and Conduction Disease: A Marker of Reactive Arthritis"],"prefix":"10.1111","volume":"31","author":[{"given":"Joshua M.","family":"Lader","sequence":"first","affiliation":[{"name":"Leon H. Charney Division of Cardiology New York University School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Lam","sequence":"additional","affiliation":[{"name":"Leon H. 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