{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:19:16Z","timestamp":1773213556641,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T00:00:00Z","timestamp":1411516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Scleroderma is a connective tissue disease characterized by diffuse vascular lesions and fibrosis of the skin and major organs including lungs, kidneys, and heart. When cardiac involvement is clinically evident, it is recognized as a poor prognostic factor. The early detection of cardiac involvement in scleroderma would be desirable both for implementation of preventive measures in the early stages of the disease and for optimal treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Left (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) and right (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) ventricular function were examined in 31 scleroderma patients and 21 healthy controls. Conventional and tissue Doppler echocardiography was used to evaluate systolic and diastolic function. Systolic indices including systolic (S) velocity, isovolumetric acceleration (<jats:styled-content style=\"fixed-case\">IVA<\/jats:styled-content>), ejection time (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>), and isovolumetric contraction time (<jats:styled-content style=\"fixed-case\">IVCT<\/jats:styled-content>) were measured. Early diastolic (E) velocity, late diastolic (A) velocity, E\/A and E\u2019\/A\u2019 ratios, isovolumetric relaxation time (<jats:styled-content style=\"fixed-case\">IVRT<\/jats:styled-content>), and deceleration time (<jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content>) were the diastolic measurements obtained. Myocardial performance index (Tei index) calculated by 2 different methods was used to assess global ventricular function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our study; mitral S velocity, biventricular <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>, E\u2019, E\/A, E\u2019\/A\u2019, <jats:styled-content style=\"fixed-case\">RV IVA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LV IVA<\/jats:styled-content>, and tricuspid S velocity were significantly lower in scleroderma patients. Mitral <jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IVCT<\/jats:styled-content>, and biventricular <jats:styled-content style=\"fixed-case\">IVRT<\/jats:styled-content>, were significantly higher in scleroderma patients (P\u00a0&lt;\u00a00.0001). In addition, <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> Tei indices were significantly increased in scleroderma patients compared with the control group (P\u00a0&lt;\u00a00.0001 and P\u00a0&lt;\u00a00.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In scleroderma patients, global function was depressed prior to the onset of clinical symptoms. Biventricular diastolic and systolic function abnormalities were also observed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12774","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T11:33:26Z","timestamp":1411558406000},"page":"912-919","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Global Function of the Heart in Scleroderma Patients"],"prefix":"10.1111","volume":"32","author":[{"given":"Demet Menekse","family":"Gerede","sequence":"first","affiliation":[{"name":"Department of Cardiology Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel","family":"Turhan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Refika","family":"Hural","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ankara University 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