{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:38:51Z","timestamp":1791221931789,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Our aim was to investigate left ventricular (LV) mechanics estimated by two\u2010 (2DE) and three\u2010dimensional echocardiography (3DE) strains in subjects with type 2 diabetes mellitus (DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included 50 untreated normotensive DM subjects and 50 healthy controls similar by sex and age. All the subjects underwent adequate laboratory analyses and complete 2DE and 3DE examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Left ventricular mechanics, assessed by 2DE, was impaired in all three directions. Global longitudinal 3DE strain was significantly decreased in the DM group in comparison with the controls (\u221217.8\u00a0\u00b1\u00a02.5 vs. \u221219.1\u00a0\u00b1\u00a02.7%, P\u00a0=\u00a00.014). Similar results were found for 3DE global circumferential strain (\u221218.9\u00a0\u00b1\u00a02.9 vs. \u221220.4\u00a0\u00b1\u00a03.2%, P\u00a0=\u00a00.01), 3DE global radial strain (40.3\u00a0\u00b1\u00a06.9 vs. 43.1\u00a0\u00b1\u00a07.3%, P\u00a0=\u00a00.035), and 3DE global area strain (\u221229.2\u00a0\u00b1\u00a03.7 vs. \u221231\u00a0\u00b1\u00a04%, P\u00a0=\u00a00.024). LV torsion was similar between the DM patients and the controls (2.1\u00a0\u00b1\u00a00.6 vs. 1.9\u00a0\u00b1\u00a00.5 \u00b0\/cm, P\u00a0=\u00a00.073); whereas LV untwisting rate was significantly increased in the DM subjects (\u2212114\u00a0\u00b1\u00a026 vs. \u201096 \u00b123 \u00b0\/s, P\u00a0&lt;\u00a00.001). A multivariate analysis showed that 3DE global longitudinal and area myocardial functions were associated with HbA1c independently of 3DE LV mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Left ventricular deformation obtained by 3DE is significantly impaired in the type 2 DM patients. HbA1c is independently associated with LV mechanics that implies that early anti\u2010diabetic therapy and normalization of the fasting glucose level and HbA1c could impede further cardiac damage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12790","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T09:10:50Z","timestamp":1412673050000},"page":"947-955","source":"Crossref","is-referenced-by-count":49,"title":["Left Ventricular Mechanics in Untreated Normotensive Patients with Type 2 Diabetes Mellitus: A Two\u2010 and Three\u2010dimensional Speckle Tracking Study"],"prefix":"10.1111","volume":"32","author":[{"given":"Marijana","family":"Tadic","sequence":"first","affiliation":[{"name":"Department of Cardiology University Clinical Hospital Center \u201cDr. Dragisa Misovic\u2014Dedinje\u201d Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Ilic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Clinical Hospital Center \u201cDr. Dragisa Misovic\u2014Dedinje\u201d Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Cuspidi","sequence":"additional","affiliation":[{"name":"Clinical Research Unit University of Milan\u2010Bicocca and Istituto Auxologico Italiano Meda Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana","family":"Stojcevski","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Clinical Hospital Center \u201cDr. Dragisa Misovic\u2014Dedinje\u201d Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branislava","family":"Ivanovic","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology Clinical Center of Serbia Belgrade Serbia"},{"name":"Faculty of Medicine Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljiljana","family":"Bukarica","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljilja","family":"Jozika","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Clinical Hospital Center \u201cDr. Dragisa Misovic\u2014Dedinje\u201d Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Celic","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Clinical Hospital Center \u201cDr. Dragisa Misovic\u2014Dedinje\u201d Belgrade Serbia"},{"name":"Faculty of Medicine Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-012-0272-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2012.02924.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2012.06.005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.07.017"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2013.810235"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jet075"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.02.016"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12389"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.06.063"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.09.007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep097"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.11.018"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.07.143"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.955542"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-S067"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.12.014"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90385-Z"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1067\/mje.2002.120202"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.08.023"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12079"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-008-0624-5"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20030153"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.2.463"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016108785909715"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-11-147"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0408"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.12.051"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.12790","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.12790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:58:20Z","timestamp":1696348700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.12790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,7]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/echo.12790"],"URL":"https:\/\/doi.org\/10.1111\/echo.12790","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,7]]}}}