{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:09:52Z","timestamp":1773115792812,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Background<\/jats:title>The aim of this study was to assess whether epicardial fat thickness (EFT<\/jats:styled-content>) is associated with the severity of heart failure in patients with nonischemic dilated cardiomyopathy (NICMP<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>The study group was composed of 93 patients with NICMP<\/jats:styled-content> and38 age\u2010 and sex\u2010matched healty individuals as the control group. The EFT<\/jats:styled-content> was identified during end\u2010systole at the point on the free wall of the right ventricle.<\/jats:p><\/jats:sec>Results<\/jats:title>Patients with NICMP<\/jats:styled-content> had significantly lower mean EFT<\/jats:styled-content> than those in the control group (4.1\u00a0\u00b1\u00a00.8 vs. 6.1\u00a0\u00b1\u00a01.8\u00a0mm, P\u00a0<\u00a00.001). EFT<\/jats:styled-content> was thinnest in patients with New York Heart Association (NYHA)<\/jats:styled-content> functional class III<\/jats:styled-content> or IV<\/jats:styled-content> (3.5\u00a0\u00b1\u00a00.5, P\u00a0<\u00a00.001). There was a significant correlation between EFT<\/jats:styled-content>, left ventricle EF<\/jats:styled-content> (r\u00a0=\u00a00.540 P\u00a0<\u00a00.001), and B\u2010type natriuretic peptide (BNP<\/jats:styled-content>) (r\u00a0=\u00a0\u22120.695, P\u00a0<\u00a00.001) values in patients with NICMP<\/jats:styled-content>. In addition, when EFT<\/jats:styled-content> was corrected for BMI<\/jats:styled-content>, EFT<\/jats:styled-content>\/BMI<\/jats:styled-content> was lower in patients with NYHA<\/jats:styled-content> functional class III\u2013IV than patients with NYHA<\/jats:styled-content> class I\u2013II and control group (0.13\u00a0\u00b1\u00a00.01, 0.16\u00a0\u00b1\u00a00.02, 0.23\u00a0\u00b1\u00a00.04, respectively; P\u00a0<\u00a00.001). There was a significant correlation between EFT<\/jats:styled-content>\/BMI<\/jats:styled-content>, left ventricle EF<\/jats:styled-content> (r\u00a0=\u00a00.489, P\u00a0<\u00a00.001), and BNP<\/jats:styled-content> (r\u00a0=\u00a0\u22120.549, P\u00a0<\u00a00.001) in patients with NICMP<\/jats:styled-content>. In multivariate regression analysis, EFT<\/jats:styled-content> (P\u00a0=\u00a00.009), BNP<\/jats:styled-content> (P\u00a0=\u00a00.039), and left atrium volume index (P\u00a0=\u00a00.039) were independently associated with impaired functional status.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Echocardiographic EFT<\/jats:styled-content> is an inexpensive, simple, and readily available marker that may be used to asses the severity of chronic heart failure in patients with NICMP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12796","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T09:42:05Z","timestamp":1416822125000},"page":"740-748","source":"Crossref","is-referenced-by-count":24,"title":["Relation of Epicardial Fat Thickness to the Severity of Heart Failure in Patients with Nonischemic Dilated Cardiomyopathy"],"prefix":"10.1111","volume":"32","author":[{"given":"Mehmet 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