{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T05:38:26Z","timestamp":1700804306752},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T00:00:00Z","timestamp":1424995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We evaluated the diagnostic value of resting echocardiographic findings including total heart calcification (<jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content>) score in combination with dobutamine stress echocardiography (<jats:styled-content style=\"fixed-case\">DSE<\/jats:styled-content>) for detection of myocardial ischemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Altogether, 110 patients with suspected angina pectoris underwent resting echocardiography and <jats:styled-content style=\"fixed-case\">DSE<\/jats:styled-content>. On the basis of resting echocardiography, we determined the <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> score, left anterior descending artery diastole\u2010to\u2010systole velocity ratio (<jats:styled-content style=\"fixed-case\">LAD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DSVR<\/jats:styled-content>), and positive myocardial velocity during isovolumic relaxation phase (V<jats:sub>IVR<\/jats:sub>) detected by color\u2010coded tissue <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>oppler imaging. Myocardial ischemia was diagnosed by a 25% or greater reduction in the internal diameter of major coronary vessels with impaired fractional flow reserve (<jats:styled-content style=\"fixed-case\">FFR<\/jats:styled-content> \u22640.80).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DSE<\/jats:styled-content> had excellent specificity (89%) but modest sensitivity (52%) for wall\u2010motion abnormality (<jats:styled-content style=\"fixed-case\">WMA<\/jats:styled-content>) analysis. Multivariate analysis showed that <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> score \u22652 (odds ratio and 95% confidence interval: 4.49 [2.29\u201310.6]; P\u00a0=\u00a00.018), <jats:styled-content style=\"fixed-case\">LAD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DSVR<\/jats:styled-content> \u22641.5 (6.43 [1.39\u201320.3], P\u00a0=\u00a00.019), and duration of positive V<jats:sub>IVR<\/jats:sub> \u226571\u00a0msec (7.93 [3.72\u201312.1]; P\u00a0&lt;\u00a00.001) were independent predictors of ischemia. The combination of inducible <jats:styled-content style=\"fixed-case\">WMA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> score yielded significantly higher sensitivity for ischemia detection than the inducible <jats:styled-content style=\"fixed-case\">WMA<\/jats:styled-content> alone (80% vs. 52%, P\u00a0=\u00a00.0008). Using receiver operating characteristics analyses, adding all three resting echocardiographic findings to clinical variables plus inducible <jats:styled-content style=\"fixed-case\">WMA<\/jats:styled-content> further improved prediction of ischemia (P\u00a0=\u00a00.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Integration of <jats:styled-content style=\"fixed-case\">DSE<\/jats:styled-content> and resting echocardiographic findings describing degree of heart calcification, impaired <jats:styled-content style=\"fixed-case\">LAD<\/jats:styled-content> flow, and extent of delayed ejection motion of the myocardium improves detection of coronary angiogram\u2010based <jats:styled-content style=\"fixed-case\">FFR<\/jats:styled-content>\u2010guided ischemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12800","type":"journal-article","created":{"date-parts":[[2015,2,28]],"date-time":"2015-02-28T04:43:03Z","timestamp":1425098583000},"page":"993-1002","source":"Crossref","is-referenced-by-count":3,"title":["Value of Resting Echocardiographic Findings and Dobutamine Stress Echocardiography for Diagnosing Myocardial Ischemia in Patients with Suspected Angina Pectoris"],"prefix":"10.1111","volume":"32","author":[{"given":"Hiroto","family":"Utsunomiya","sequence":"first","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Los Angeles California"},{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Masada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Shimonaga","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadanao","family":"Higaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitaka","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine 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