{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:58:57Z","timestamp":1792580337468,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T00:00:00Z","timestamp":1413590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Left atrial (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>) dilation is associated with worse prognosis in various clinical situations including chronic mitral regurgitation (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>). Real time three\u2010dimensional echocardiography (3<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>) has allowed a better assessment of <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> volumes and function. Little is known about <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> size and function in early postoperative period in symptomatic patients with chronic organic <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>. We aimed to investigate these aspects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>By means of 3<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>, 43 patients with symptomatic chronic organic <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> were prospectively studied before and 30\u00a0days after surgery (repair or bioprosthetic valve replacement). Twenty subjects were studied as controls. Maximum (Vol\u2010max), minimum, and preatrial contraction <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> volumes were measured and total, passive, and active <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> emptying fractions were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before surgery patients had higher <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> volumes (P\u00a0&lt;\u00a00.001) but smaller <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> emptying fractions than controls (P\u00a0&lt;\u00a00.01). After surgery there was a reduction in all 3 <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> volumes and an increase in active atrial emptying fraction (<jats:styled-content style=\"fixed-case\">AAEF<\/jats:styled-content>). Multivariate analysis showed that independent predictors of early postoperative Vol\u2010max reduction were preoperative diastolic blood pressure (coefficient\u00a0=\u00a0\u22120.004; P\u00a0=\u00a00.02), lateral mitral annular early diastolic velocity (e\u2032) (coefficient\u00a0=\u00a00.023; P\u00a0=\u00a00.008), and the mean transmitral diastolic gradient increment (coefficient\u00a0=\u00a0\u22120.035; P\u00a0&lt;\u00a00.001). Furthermore, e\u2032 was also independently associated with <jats:styled-content style=\"fixed-case\">AAEF<\/jats:styled-content> increase (odds ratio\u00a0=\u00a01.66, P\u00a0=\u00a00.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> reverse remodeling and functional improvement occur after successful surgery of symptomatic organic <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> regardless of surgical technique. Diastolic blood pressure and transmitral mean gradient augmentation are variables negatively related to Vol\u2010max reduction. Besides, e\u2032 is positively correlated with both Vol\u2010max reduction and <jats:styled-content style=\"fixed-case\">AAEF<\/jats:styled-content> increase.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12817","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T10:26:40Z","timestamp":1413628000000},"page":"1122-1130","source":"Crossref","is-referenced-by-count":20,"title":["Early Improvement in Left Atrial Remodeling and Function after Mitral Valve Repair or Replacement in Organic Symptomatic Mitral Regurgitation Assessed by Three\u2010Dimensional Echocardiography"],"prefix":"10.1111","volume":"32","author":[{"given":"David C. S.","family":"Le Bihan","sequence":"first","affiliation":[{"name":"Dante Pazzanese Institute of Cardiology Sao Paulo Brazil"},{"name":"Escola Paulista de Medicina\u2014Universidade Federal de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorival Julio","family":"Della Togna","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Institute of Cardiology Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo B. M.","family":"Barretto","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Institute of Cardiology Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Eduardo","family":"Assef","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Institute of Cardiology Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia Romero","family":"Machado","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Institute of Cardiology Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auristela Isabel de Oliveira","family":"Ramos","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Institute of Cardiology Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo","family":"Abdulmassih Neto","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Institute of Cardiology Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir Ambrosio","family":"Mois\u00e9s","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina\u2014Universidade Federal de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda G. M. R.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Dante Pazzanese Institute of Cardiology Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando","family":"Campos","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina\u2014Universidade Federal de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/76.5.467"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.05.031"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2011.01489.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.4.835"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.1.23"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.059"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm199"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.03.020"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.122150"},{"key":"e_1_2_6_12_1","first-page":"27","article-title":"Left atrial volumes, function and work before and after mitral valve repair in chronic mitral regurgitation","volume":"13","author":"Dardas PS","year":"2004","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.12.017"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.05.011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.10.029"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.07.013"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.01.015"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2010.01329.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01056-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.508812"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2011.01393.x"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.12817","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.12817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:13:12Z","timestamp":1696320792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.12817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,18]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/echo.12817"],"URL":"https:\/\/doi.org\/10.1111\/echo.12817","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,18]]}}}