{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:45:59Z","timestamp":1777074359940,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Background<\/jats:title>Tricuspid annular plane systolic excursion (TAPSE<\/jats:styled-content>) has emerged as a novel and reliable measure of right ventricular (RV<\/jats:styled-content>) function. The purpose of this study was to determine the effect of pulmonary hypertension (PH<\/jats:styled-content>) therapy on TAPSE<\/jats:styled-content> in pediatric patients and compare TAPSE<\/jats:styled-content> to other quantitative measures of RV<\/jats:styled-content> function.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective review of medical records and echocardiograms of patients in the PH<\/jats:styled-content> clinic from January 2011 to August 2013 was done. Echocardiograms were analyzed prior to initiation or addition of a PH<\/jats:styled-content> drug and at least 8\u00a0weeks later. Following quantitative measures of RV<\/jats:styled-content> function were compared: TAPSE<\/jats:styled-content>, TAPSE<\/jats:styled-content> age\u2010based z\u2010score, RV<\/jats:styled-content> fractional area change (RVFAC<\/jats:styled-content>), tricuspid annular S\u2032, tricuspid inflow E\/tricuspid annular E\u2032 velocity (TV<\/jats:styled-content> E\/E\u2032), and RV<\/jats:styled-content> myocardial performance index (RVMPI<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 37 patients included in this study (median age 0.6\u00a0years), 23 (62.2%) were treatment naive and others had a new PH<\/jats:styled-content> drug added to their regimen at the time of the baseline echocardiogram. The median duration between the baseline and follow\u2010up echocardiogram was 8 (2\u201325) months. There was a significant improvement in TAPSE<\/jats:styled-content> and TAPSE<\/jats:styled-content> age\u2010based z\u2010score on the follow\u2010up echocardiogram. RVFAC<\/jats:styled-content>, tricuspid S\u2032, TV<\/jats:styled-content> E\/E\u2032, and RVMPI<\/jats:styled-content> did not show a statistically significant change.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In contrast to the other echocardiographic markers of RV<\/jats:styled-content> function, TAPSE<\/jats:styled-content>, and TAPSE<\/jats:styled-content> age\u2010based z\u2010score significantly improve after initiation or addition of PH<\/jats:styled-content> therapy and can be used for serial noninvasive monitoring of RV<\/jats:styled-content> function in pediatric PH<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12835","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T07:06:56Z","timestamp":1414998416000},"page":"1228-1232","source":"Crossref","is-referenced-by-count":14,"title":["Improvement in Tricuspid Annular Plane Systolic Excursion with Pulmonary Hypertension Therapy in Pediatric Patients"],"prefix":"10.1111","volume":"32","author":[{"given":"Maria","family":"Bano","sequence":"first","affiliation":[{"name":"Emory University School of Medicine and Children's Healthcare of Atlanta Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usama B.","family":"Kanaan","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine and Children's Healthcare of Atlanta Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra C.","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine and Children's Healthcare of Atlanta Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"McCracken","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine and Children's Healthcare of Atlanta Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Morrow","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine and Children's Healthcare of Atlanta Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew E.","family":"Oster","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine and Children's Healthcare of Atlanta Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine and Children's Healthcare of Atlanta Atlanta 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