{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:23:19Z","timestamp":1780485799811,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"K\u00c3\u00b6ln Fortune Program, Faculty of Medicine, University of Cologne, Cologne, Germany","award":["121\/2008"],"award-info":[{"award-number":["121\/2008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Background<\/jats:title>Cardiac dysfunction frequently complicates the clinical course of patients with end\u2010stage renal failure (ESRF<\/jats:styled-content>). Recently, we observed abnormal longitudinal cardiac rotation (LR<\/jats:styled-content>) among patients with ESRF<\/jats:styled-content>. In this study, we sought to quantify LR<\/jats:styled-content> mechanics in patients undergoing hemodialysis (HD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty\u2010four subjects, 12 ESRF<\/jats:styled-content> patients (58% male; age 17.5\u00a0\u00b1\u00a04.4\u00a0years) receiving HD<\/jats:styled-content>, and 12 aged\u2010matched controls, were prospectively studied. Patients underwent echocardiographic studies before and after HD<\/jats:styled-content>. LR<\/jats:styled-content> mechanics were quantified with two\u2010dimensional speckle tracking echocardiography. Peak systolic left ventricular (LV<\/jats:styled-content>) longitudinal strain and displacement measurements were obtained in all subjects.<\/jats:p><\/jats:sec>Results<\/jats:title>LR<\/jats:styled-content> mechanics were successfully quantified in all subjects using 5 key echocardiographic features of LR<\/jats:styled-content>. We identified two different inhomogeneous LR<\/jats:styled-content> motion patterns in 41.7% of ESRF<\/jats:styled-content> patients, characterized by a delayed timing of LR<\/jats:styled-content> or increased segmental apical rotation. Inhomogeneous LR<\/jats:styled-content> patterns were not found in controls. Timing of early\u2010systolic counterclockwise LR<\/jats:styled-content> increased after HD<\/jats:styled-content> (P\u00a0=\u00a00.006). In patients, late\u2010systolic clockwise LR<\/jats:styled-content> occurred earlier (P\u00a0=\u00a00.043), and showed a significant prolongation after HD<\/jats:styled-content> (P\u00a0=\u00a00.003). Longitudinal strain was significantly impaired in patients (P\u00a0=\u00a00.015), and further decreased after HD<\/jats:styled-content> (P\u00a0<\u00a00.0001). Strong correlations were observed between strain and displacement parameters and LR<\/jats:styled-content> mechanics.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Quantifying LR<\/jats:styled-content> using speckle tracking echocardiography was feasible, easy, and reproducible. Inhomogeneous LR<\/jats:styled-content> motion patterns were demonstrated in a large proportion of patients with ESRF<\/jats:styled-content>. LV<\/jats:styled-content> dysfunction seems the most important determinant of inhomogeneous LR<\/jats:styled-content>. Further studies are required to validate these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12842","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T04:32:48Z","timestamp":1417494768000},"page":"1250-1260","source":"Crossref","is-referenced-by-count":12,"title":["Inhomogeneous Longitudinal Cardiac Rotation and Impaired Left Ventricular Longitudinal Strain in Children and Young Adults with End\u2010Stage Renal Failure Undergoing Hemodialysis"],"prefix":"10.1111","volume":"32","author":[{"given":"Ruth","family":"Lagies","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, Heart Center Cologne University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodo B.","family":"Beck","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Nephrology University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar S.","family":"Sheta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Cairo University Children's Hospital (CUCH) Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Wei\u00df","sequence":"additional","affiliation":[{"name":"Institute for Medical Statistics, Informatics and Epidemiology (IMSIE) University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayanswami","family":"Sreeram","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Heart Center Cologne University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris E. 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