{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:31:04Z","timestamp":1770820264727,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Paroxysmal supraventricular arrhythmias (<jats:styled-content style=\"fixed-case\">SVA<\/jats:styled-content>s) frequently occur in patients with atrial septal aneurysm (ASA). The aim of the current study was to evaluate the electrocardiographic (P\u2010wave duration and dispersion) and echocardiographic (atrial electromechanical delay, AEMD) noninvasive indicators of atrial conduction heterogeneity in healthy ASA subjects without interatrial shunt and to assess the AEMD role in predicting the SVAs onset in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>One hundered ASA patients (41 males, mean age of 32.5\u00a0\u00b1\u00a08\u00a0years) and 100 healthy subjects used as controls, matched for age and gender, were studied for the occurrence of SVAs during a 4\u2010year follow\u2010up, through 30\u2010day external loop recorder (ELR) monitoring performed every 3\u00a0months. ASAs were diagnosed by transthoracic echocardiography based on the criteria of a minimal aneurismal base of \u226515\u00a0mm and an excursion of \u226510\u00a0mm. Intra\u2010AEMD and inter\u2010AEMD of both atria were measured through tissue Doppler echocardiography. P\u2010wave dispersion (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) was carefully measured using 12\u2010lead electrocardiogram (ECG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the healthy control group, the ASA group showed a statistically significant increase in inter\u2010AEMD, intra\u2010left AEMD, maximum P\u2010wave duration, and PD. Dividing the ASA group into 2 subgroups (patients with or without SVAs), the inter\u2010AEMD, intra\u2010left AEMD, P max, and PD were significantly higher in the subgroup with SVAs compared to the subgroup without SVAs. There were significant good correlations of intra\u2010left AEMD and inter\u2010AEMD with PD. A cutoff value of 40.1\u00a0msec for intra\u2010left AEMD had a sensitivity of 82% and a specificity of 83% in identifying ASA patients at risk for SVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results showed that the echocardiographic AEMD indices (intra\u2010left and inter\u2010AEMD) and the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> were significantly increased in healthy ASA subjects without interatrial shunt. PD and AEMD represent noninvasive, inexpensive, useful, and simple parameters to assess the SVAs' risk in ASA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12908","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T09:11:40Z","timestamp":1425373900000},"page":"1504-1514","source":"Crossref","is-referenced-by-count":17,"title":["Atrial Septal Aneurysms and Supraventricular Arrhythmias: The Role of Atrial Electromechanical Delay"],"prefix":"10.1111","volume":"32","author":[{"given":"Vincenzo","family":"Russo","sequence":"first","affiliation":[{"name":"Chair of Cardiology Second University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rago","sequence":"additional","affiliation":[{"name":"Chair of Cardiology Second University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Di Meo","sequence":"additional","affiliation":[{"name":"Chair of Cardiology Second University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Antonio","family":"Papa","sequence":"additional","affiliation":[{"name":"Chair of Cardiology Second University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine","family":"Ciardiello","sequence":"additional","affiliation":[{"name":"H.T. 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