{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T22:50:13Z","timestamp":1725490213472},"reference-count":5,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Tuberous sclerosis complex (<jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content>) is a neurocutaneous syndrome and multisystem disorder with autosomal dominant inheritance and variable penetrance. Cardiac rhabdomyomas have been reported in 50\u201364% of patients with <jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content> and transthoracic echocardiography is established as the primary imaging modality for their detection. The precise functional assessment of the left ventricle in these patients requires clarification. We report a case of a 19\u2010year\u2010old male with known <jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content> who was referred for outpatient transthoracic echocardiography (<jats:styled-content style=\"fixed-case\">TTE<\/jats:styled-content>) to investigate for the presence of cardiac rhabdomyomas. <jats:styled-content style=\"fixed-case\">TTE<\/jats:styled-content> demonstrated multiple rhabdomyomas with a normal ejection fraction but altered global and regional deformation on speckle tracking. The regional longitudinal strain was notably reduced in the anterior septum (\u221211%) and inferior septum (\u221215%). The global circumferential strain (<jats:styled-content style=\"fixed-case\">GCS<\/jats:styled-content>) was significantly reduced at \u221215.6%. The distribution of regional circumferential strain reduction for the mid\u2010ventricular segment correlated with the location of cardiac rhabdomyomas.<\/jats:p>","DOI":"10.1111\/echo.12921","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T10:57:29Z","timestamp":1425380249000},"page":"1432-1434","source":"Crossref","is-referenced-by-count":1,"title":["Imaging Tuberous Sclerosis: The Incremental Benefit of Three\u2010Dimensional and Speckle Tracking Echocardiography"],"prefix":"10.1111","volume":"32","author":[{"given":"Pankaj","family":"Garg","sequence":"first","affiliation":[{"name":"Cardiothoracic Unit Chesterman Wing Northern General Hospital Sheffield Teaching Hospitals NHS Foundation Trust Sheffield United Kingdom"},{"name":"Multidisciplinary Cardiovascular Research Centre &amp; Leeds Institute for Cardiovascular and Metabolic Medicine University of Leeds Leeds United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarique A.","family":"Musa","sequence":"additional","affiliation":[{"name":"Multidisciplinary Cardiovascular Research Centre &amp; Leeds Institute for Cardiovascular and Metabolic Medicine University of Leeds Leeds United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Ripley","sequence":"additional","affiliation":[{"name":"Multidisciplinary Cardiovascular Research Centre &amp; Leeds Institute for Cardiovascular and Metabolic Medicine University of Leeds Leeds United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,3]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(85)90508-9"},{"key":"e_1_2_2_3_1","first-page":"1432","volume-title":"Moss and Adams\u2019 Heart Disease in Infants, Children, and Adolescents Including the Fetus and Young Adult","author":"Marx GR","year":"2001"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2008.00850.x"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes307"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht098"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.12921","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.12921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:12:24Z","timestamp":1695550344000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.12921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,3]]},"references-count":5,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/echo.12921"],"URL":"https:\/\/doi.org\/10.1111\/echo.12921","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,3]]}}}