{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:11:46Z","timestamp":1771233106750,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Reduction in mitral regurgitation (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) after transcatheter aortic valve replacement (<jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>) has previously been reported. However, the hemodynamic effects of <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> have not been previously evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 571 patients who underwent <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content> from December 2010 to December 2013. We studied 20 patients with moderate or severe preprocedural functional mitral regurgitation (<jats:styled-content style=\"fixed-case\">FMR<\/jats:styled-content>) who also had a follow\u2010up transthoracic echocardiography (<jats:styled-content style=\"fixed-case\">TTE<\/jats:styled-content>) examination between 90 and 360\u00a0days (median 213\u00a0days) after <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content> (Significant <jats:styled-content style=\"fixed-case\">FMR<\/jats:styled-content> Group). We also studied age\u2010 and gender\u2010matched 20 patients with mild or lesser <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> (Nonsignificant <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> Group). Left ventricular functional measurements were assessed using echocardiography before and after <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>. Left ventricular outflow tract stroke volume measurements using pulsed\u2010wave Doppler (<jats:styled-content style=\"fixed-case\">SV<jats:sub>LVOT<\/jats:sub><\/jats:styled-content>) were calculated as a representative of systolic forward flow, and stroke volume by the Simpson's method (SV<jats:sub>Simpson<\/jats:sub>) was calculated as a parameter of degree of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> contraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> grade improved in 22 of 40 patients after <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>. In both groups, <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> level decreased, left ventricular ejection fraction increased, and <jats:styled-content style=\"fixed-case\">SV<jats:sub>LVOT<\/jats:sub><\/jats:styled-content> increased after <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>. SV<jats:sub>Simpson<\/jats:sub> increased in the Nonsignificant <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> Group and remained unchanged in the Significant <jats:styled-content style=\"fixed-case\">FMR<\/jats:styled-content> Group. Vena contracta width of <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">MRVC<\/jats:styled-content>) decreased in the Significant <jats:styled-content style=\"fixed-case\">FMR<\/jats:styled-content> Group. Using multivariable analysis in the Significant <jats:styled-content style=\"fixed-case\">FMR<\/jats:styled-content> Group, the increase in <jats:styled-content style=\"fixed-case\">SV<jats:sub>LVOT<\/jats:sub><\/jats:styled-content> significantly correlated with the decrease in <jats:styled-content style=\"fixed-case\">MRVC<\/jats:styled-content> (P\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SV<jats:sub>LVOT<\/jats:sub><\/jats:styled-content> increased significantly after <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">FMR<\/jats:styled-content>. In these patients, increase in <jats:styled-content style=\"fixed-case\">SV<jats:sub>LVOT<\/jats:sub><\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content> was associated with decrease in severity of <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12936","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T04:49:32Z","timestamp":1427431772000},"page":"1621-1627","source":"Crossref","is-referenced-by-count":9,"title":["Significant Reduction in Mitral Regurgitation Volume Is the Main Contributor for Increase in Systolic Forward Flow in Patients with Functional Mitral Regurgitation after Transcatheter Aortic Valve Replacement: Hemodynamic Analysis Using Echocardiography"],"prefix":"10.1111","volume":"32","author":[{"given":"Yuji","family":"Itabashi","sequence":"first","affiliation":[{"name":"Noninvasive Cardiac Laboratory Cedars\u2010Sinai Heart Institute Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Shibayama","sequence":"additional","affiliation":[{"name":"Heart Center Tokyo Bay Urayasu\/Ichikawa Medical Center Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotsugu","family":"Mihara","sequence":"additional","affiliation":[{"name":"Noninvasive Cardiac Laboratory Cedars\u2010Sinai Heart Institute Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Noninvasive Cardiac Laboratory Cedars\u2010Sinai Heart Institute Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Berdejo","sequence":"additional","affiliation":[{"name":"Noninvasive Cardiac Laboratory Cedars\u2010Sinai Heart Institute Los Angeles 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