{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:16:19Z","timestamp":1790061379700,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Epicardial adipose tissue (<jats:styled-content style=\"fixed-case\">EAT<\/jats:styled-content>) is a new independent marker of coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>). The aim of this study was to investigate the relationship between epicardial fat thickness (<jats:styled-content style=\"fixed-case\">EFT<\/jats:styled-content>) and endothelial dysfunction (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) in patients with type I diabetes mellitus (<jats:styled-content style=\"fixed-case\">TIDM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Seventy\u2010six type I diabetic patients (diabetes duration 11.7\u00a0\u00b1\u00a08,1\u00a0years, aged 30.6\u00a0\u00b1\u00a010\u00a0years; female\/male: 38\/38) and 36 healthy controls were enrolled into the study. Fasting plasma glucose (<jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>), lipid panel, glycosylated hemoglobin (HbA1C), high\u2010sensitive C\u2010reactive protein (hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), and fibrinogen levels were determined. <jats:styled-content style=\"fixed-case\">EFT<\/jats:styled-content> was measured via two\u2010dimensional (2D) M\u2010mode echocardiography. Endothelial function was assessed as flow\u2010mediated dilatation (<jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>) at the brachial artery using high\u2010resolution ultrasound. <jats:styled-content style=\"fixed-case\">EFT<\/jats:styled-content> was significantly higher in patients compared to controls (3.56\u00a0\u00b1 0.48\u00a0mm vs. 3.03\u00a0\u00b1\u00a00.48\u00a0mm, P\u00a0&lt;\u00a00.001). In addition, significant differences were observed between the patient and control groups in terms of <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> (6.70% \u00b1 1.63 vs. 9.99% \u00b1 1.84, respectively, P\u00a0&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">EFT<\/jats:styled-content> was shown to be correlated negatively with <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> (r: \u22120.94, P\u00a0&lt;\u00a00.001) and positively with hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (r: 0.41, P\u00a0&lt;\u00a00.001) and fibrinogen (r: 0. 31, P\u00a0=\u00a00.007). Multiple regression analysis showed <jats:styled-content style=\"fixed-case\">EFT<\/jats:styled-content> to be an independent factor influencing the endothelial function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was inverse relationship between <jats:styled-content style=\"fixed-case\">EFT<\/jats:styled-content> and endothelial function in this study. <jats:styled-content style=\"fixed-case\">EFT<\/jats:styled-content> measured easily by transthoracic echocardiography may be a useful parameter in the assessment of patients with <jats:styled-content style=\"fixed-case\">TIDM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12960","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T05:16:38Z","timestamp":1430198198000},"page":"1745-1753","source":"Crossref","is-referenced-by-count":21,"title":["The Relationship between Epicardial Fat Thickness and Endothelial Dysfunction in Type I Diabetes 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