{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:23:23Z","timestamp":1781274203554,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T00:00:00Z","timestamp":1433980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Northern County Council"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Role of right atrial mechanics has not been studied in idiopathic pulmonary arterial hypertension (<jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content>). We sought to investigate the correlation between the right sided, particularly right atrial mechanics, hemodynamic parameters, and functional capacity prior to initiation of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Twenty\u2010five subjects (63\u00a0\u00b1\u00a017\u00a0years, 13 males) with newly diagnosed <jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content> by right heart catheterization (<jats:styled-content style=\"fixed-case\">RHC<\/jats:styled-content>) underwent speckle tracking echocardiography (<jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>) of the right ventricle (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) and right atrium (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>). All the patients had a six\u2010minute walk test (6<jats:styled-content style=\"fixed-case\">MWD<\/jats:styled-content>) performed, functional class (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>) assessed, and plasma <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\u2010pro<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> estimated. <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> strain imaging of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> was performed offline. <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> of the <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> myocardium yielded characteristic strain (S%) and strain rate (<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>) curves with clear delineation of its reservoir (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>%), conduit (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> E), and booster pump functions (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> A). In <jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> RHC<\/jats:styled-content>\u2010obtained pulmonary vascular resistance (<jats:styled-content style=\"fixed-case\">PVR<\/jats:styled-content>) and pulmonary artery systolic pressure (<jats:styled-content style=\"fixed-case\">PASP<\/jats:styled-content>), respectively, were 7.3\u00a0\u00b1\u00a05.6 Wood units and 66\u00a0\u00b1\u00a024\u00a0mmHg. <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>% was associated negatively with <jats:styled-content style=\"fixed-case\">PVR<\/jats:styled-content> (r\u00a0=\u00a0\u22120.46; P\u00a0&lt;\u00a00.05) and positively with stroke volume and cardiac output (all P\u00a0&lt;\u00a00.05). Both right atrial pressure (<jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content>) obtained by <jats:styled-content style=\"fixed-case\">RHC<\/jats:styled-content> as well as <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> E had significant association with <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> (Multiple R\u00a0=\u00a00.7; P\u00a0=\u00a00. 01 and 0.007, respectively). <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> strain rate during systole and <jats:styled-content style=\"fixed-case\">RAP<\/jats:styled-content> had significant association with 6<jats:styled-content style=\"fixed-case\">MWD<\/jats:styled-content> (Multiple R\u00a0=\u00a00.7; P\u00a0=\u00a00.01 and 0.006, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Right atrium mechanics not only correlate well with <jats:styled-content style=\"fixed-case\">RHC<\/jats:styled-content>\u2010obtained hemodynamics, but also correlate with functional capacity in treatment\u2010naive <jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.12993","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T17:14:56Z","timestamp":1434734096000},"page":"46-56","source":"Crossref","is-referenced-by-count":21,"title":["Association of Right Atrial Mechanics with Hemodynamics and Physical Capacity in Patients with Idiopathic Pulmonary Arterial Hypertension: Insight from a Single\u2010Center Cohort in Northern Sweden"],"prefix":"10.1111","volume":"33","author":[{"given":"Samir Kanti","family":"Saha","sequence":"first","affiliation":[{"name":"Research and Development Division Sundsvalls Hospital Sundsvall Sweden"},{"name":"The Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"S\u00f6derberg","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Cardiology and Heart Center Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Surgery and Perioperative Sciences Clinical Physiology Ume\u00e5 University Ume\u00e5 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