{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T15:29:57Z","timestamp":1770996597794,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004266","name":"Consiliului National al Cercetarii Stiintifice din Invatamantul Superior","doi-asserted-by":"publisher","award":["PNII\u2010IDEI 246\/2008"],"award-info":[{"award-number":["PNII\u2010IDEI 246\/2008"]}],"id":[{"id":"10.13039\/501100004266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,4]]},"abstract":"Aims<\/jats:title>Survival in patients (pts) with pulmonary hypertension (PH<\/jats:styled-content>) differs between subgroups at similar levels of pressure overload. We set to analyze right ventricular (RV<\/jats:styled-content>) morphology and function in different types of PH<\/jats:styled-content> using conventional and deformation imaging echocardiography.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>Thirty\u2010four pts with PH<\/jats:styled-content>: 12 pts with idiopathic pulmonary arterial hypertension (IPAH<\/jats:styled-content>, 42.2 \u00b1 13 years), 11 pts with chronic thromboembolic PH<\/jats:styled-content> (CTEPH<\/jats:styled-content>, 50.8 \u00b1 12 years), 11 pts with Eisenmenger syndrome [ES<\/jats:styled-content> 41.2 \u00b1 15 years, 4 with atrial septal defect (ASD<\/jats:styled-content>) and 7 with ventricular septal defect (VSD<\/jats:styled-content>)], and 13 age\u2010matched healthy individuals (38.1 \u00b1 15 years) were evaluated. The following echocardiographic parameters were measured: echo\u2010derived systolic pulmonary pressure (sPAP<\/jats:styled-content>echo), RV<\/jats:styled-content> end\u2010diastolic diameter (RVEDD<\/jats:styled-content>), RV<\/jats:styled-content> wall thickness (RVWT<\/jats:styled-content>), TAPSE<\/jats:styled-content>, RV<\/jats:styled-content> fractional area change (RVFAC<\/jats:styled-content>), Tei index, peak systolic velocity of the tricuspid ring (S't), and speckle tracking\u2010derived RV<\/jats:styled-content> free wall strain. Furthermore, right heart catheterization (RHC<\/jats:styled-content>) was performed in pts with PH<\/jats:styled-content> and mean, and systolic pulmonary artery pressure (mPAP<\/jats:styled-content>cath, sPAP<\/jats:styled-content>cath), cardiac output (CO<\/jats:styled-content>), cardiac index (CO<\/jats:styled-content>i), and pulmonary vascular resistance (PVR<\/jats:styled-content>) were noted.<\/jats:p><\/jats:sec>Results<\/jats:title>The levels of mPAP<\/jats:styled-content>cath and sPAP<\/jats:styled-content>cath were similar between pts with PH<\/jats:styled-content> (pANOVA<\/jats:styled-content> = NS<\/jats:styled-content>). Patients with ES<\/jats:styled-content> had higher CO<\/jats:styled-content>i compared to other groups (2.94 \u00b1 0.79, 2.28 \u00b1 0.69, and 1.74 \u00b1 0.46 L\/min\/m2<\/jats:sup> for pts with ES<\/jats:styled-content>, IPAH<\/jats:styled-content>, and CTEPH<\/jats:styled-content> respectively, pANOVA<\/jats:styled-content> = 0.004, P post hoc ES<\/jats:styled-content> versus all other groups < 0.05). TAPSE<\/jats:styled-content>, Tei index, and S't were similar between groups and impaired versus controls (pANOVA<\/jats:styled-content> < 0.001, P post hoc between groups of patients = NS<\/jats:styled-content>). Patients with ES<\/jats:styled-content> had better RVFAC<\/jats:styled-content> (41.1 \u00b1 9, 30.5 \u00b1 10.8, 23.2 \u00b1 9.8%) and RV<\/jats:styled-content> free wall strain (\u221220.6 \u00b1 3.5, \u221216.3 \u00b1 7.5, \u221210.8 \u00b1 5%), as well as an increased thickness of the RV<\/jats:styled-content> free wall compared to other groups of patients (9.2 \u00b1 1.5, 7.2 \u00b1 1 and 7.2 \u00b1 1.6 mm for pts with ES<\/jats:styled-content>, IPAH<\/jats:styled-content> and CTEPH<\/jats:styled-content>, respectively) (pANOVA<\/jats:styled-content><0.001, P post hoc <0.05 ES<\/jats:styled-content> versus all other groups). RVFAC<\/jats:styled-content> and RV<\/jats:styled-content> free wall strain significantly correlated with CO<\/jats:styled-content>i (r = 0.53, P = 0.006 and r = \u22120.77, P < 0.001, respectively).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Patients with ES<\/jats:styled-content> have a more hypertrophied RV<\/jats:styled-content> free wall, better RV<\/jats:styled-content> performance as assessed by RVFAC<\/jats:styled-content> and RV<\/jats:styled-content> free wall strain and increased CO<\/jats:styled-content>i compared to other types of PH<\/jats:styled-content>. Furthermore, RV<\/jats:styled-content> performance appears to be less dependent on the level of pressure overload. These findings could contribute to the better survival profile of patients with ES<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13112","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T08:54:44Z","timestamp":1446800084000},"page":"546-554","source":"Crossref","is-referenced-by-count":24,"title":["Is Right Ventricular Remodeling in Pulmonary Hypertension Dependent on Etiology? An Echocardiographic Study"],"prefix":"10.1111","volume":"33","author":[{"given":"Sorin","family":"Giusca","sequence":"first","affiliation":[{"name":"Cardiology Department Emergency Institute for Cardiovascular Diseases \u201cProf. Dr. C. C. Iliescu,\u201d Bucharest Romania"},{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Popa","sequence":"additional","affiliation":[{"name":"Cardiology Department Emergency Institute for Cardiovascular Diseases \u201cProf. Dr. C. C. Iliescu,\u201d Bucharest Romania"},{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela Silvia","family":"Amzulescu","sequence":"additional","affiliation":[{"name":"Cardiology Department Emergency Institute for Cardiovascular Diseases \u201cProf. Dr. C. C. Iliescu,\u201d Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Ghiorghiu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioan Mircea","family":"Coman","sequence":"additional","affiliation":[{"name":"Cardiology Department Emergency Institute for Cardiovascular Diseases \u201cProf. Dr. C. C. Iliescu,\u201d Bucharest Romania"},{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan A.","family":"Popescu","sequence":"additional","affiliation":[{"name":"Cardiology Department Emergency Institute for Cardiovascular Diseases \u201cProf. Dr. C. C. Iliescu,\u201d Bucharest Romania"},{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Delcroix","sequence":"additional","affiliation":[{"name":"Pneumology Department Gasthuisberg Hospital Catholic University Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens\u2010Uwe","family":"Voigt","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Department Gasthuisberg Hospital Catholic University Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Ginghina","sequence":"additional","affiliation":[{"name":"Cardiology Department Emergency Institute for Cardiovascular Diseases \u201cProf. Dr. C. C. 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