{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:59:00Z","timestamp":1776815940322,"version":"3.51.2"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Transesophageal echocardiography (<jats:styled-content style=\"fixed-case\">TEE<\/jats:styled-content>) is the diagnostic gold standard for the detection of structural heart diseases as potential sources of cardiac emboli in patients with acute cerebral ischemia. We sought to determine the diagnostic yield of <jats:styled-content style=\"fixed-case\">TEE<\/jats:styled-content> in patients with acute ischemic stroke or transient ischemic attack (<jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed consecutive patients with acute cerebral ischemia who were admitted to our hospital between October 2008 and December 2011. <jats:styled-content style=\"fixed-case\">TEE<\/jats:styled-content> reports were screened for detection of cardiac source of embolism judged by the recommendation to change medical management. We performed univariate and multivariate analyses to identify predictors of clinically relevant <jats:styled-content style=\"fixed-case\">TEE<\/jats:styled-content> findings among baseline characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 3314 patients with ischemic stroke or <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TEE<\/jats:styled-content> was performed in 791 (24%) patients (mean age 64\u00a0\u00b1\u00a013 years, 589 [74%] ischemic stroke, 202 [26%] <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>). A potential cardioembolic source was found in 71 (9%) patients with patent foramen ovale with atrial septal aneurysm being the most common finding (24\/71 patients, 34%). In multivariate analysis, peripheral vascular disease (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.57; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.00\u20136.61), imaging evidence of infarction in multiple locations (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.13; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.36\u201312.58), and infarction in the posterior circulation (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.11; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.01\u20134.42) were associated with the identification of a potential cardioembolic source with <jats:styled-content style=\"fixed-case\">TEE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TEE<\/jats:styled-content> identified a potential structural cardioembolic source in nearly 10% of our selected patient population with acute ischemic stroke or <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>, thus underlining its diagnostic value. Our data suggest that patients with hitherto unknown stroke etiology should be considered for additional <jats:styled-content style=\"fixed-case\">TEE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13131","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T22:37:00Z","timestamp":1461364620000},"page":"555-561","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic Impact of Transesophageal Echocardiography in Patients with Acute Cerebral Ischemia"],"prefix":"10.1111","volume":"33","author":[{"given":"Lars\u2010Peder","family":"Pallesen","sequence":"first","affiliation":[{"name":"Dresden University Stroke Center Department of Neurology University of Technology Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaretha","family":"Ragaller","sequence":"additional","affiliation":[{"name":"Dresden University Stroke Center Department of Neurology University of Technology Dresden 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