{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:28:41Z","timestamp":1789831721797,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T00:00:00Z","timestamp":1449964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies indicated that the three\u2010dimensional features of the mitral valve (<jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content>) have a significant impact on <jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content> disease. However, quantification of <jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content> with manual tracing software was too time\u2010consuming for routine clinical practice. This study was performed to investigate the efficacy and accuracy of <jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content> quantification with a novel highly automated commercially available software package developed for this purpose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the manual tracing and automated package, two expert sonographers and one cardiologist individually analyzed three\u2010dimensional datasets acquired with transesophageal echocardiography from 74 patients (15 with functional mitral regurgitation, 32 with <jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content> prolapse, and 27 normal subjects) retrospectively. Time for analysis and inter\u2010observer agreement were compared between the two methods, and agreement of measurements was analyzed using Cronbach's \u03b1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Time for analysis using the automated package was significantly shorter than manual tracing (whole cohort, 260 \u00b1 65 vs. 381 \u00b1 68 seconds, P &lt; 0.001; functional mitral regurgitation, 234 \u00b1 42 vs. 378 \u00b1 64 seconds, P &lt; 0.001; <jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content> prolapse, 293 \u00b1 69 vs. 407 \u00b1 67 seconds, P &lt; 0.001; normal controls, 235 \u00b1 52 vs. 351 \u00b1 60 seconds, P &lt; 0.001). There was good agreement among all three observers using both methods, and measurements with the automated package agreed well with the manual tracing values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel automated software package reduced time for quantification of <jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content> with similar accuracy compared to the manual method. Automated quantification is useful and may be a key to widespread adoption of three\u2010dimensional quantification in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13135","type":"journal-article","created":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T11:05:21Z","timestamp":1450004721000},"page":"756-763","source":"Crossref","is-referenced-by-count":37,"title":["Efficacy and Accuracy of Novel Automated Mitral Valve Quantification: Three\u2010Dimensional Transesophageal Echocardiographic Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-0049","authenticated-orcid":false,"given":"Nobuyuki","family":"Kagiyama","sequence":"first","affiliation":[{"name":"Department of Cardiology The Sakakibara Heart Institute of Okayama Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misako","family":"Toki","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The Sakakibara Heart Institute of Okayama Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Medical Innovation Osaka University Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The Sakakibara Heart Institute of Okayama Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Aritaka","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The Sakakibara Heart Institute of Okayama Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Sakakibara Heart Institute of Okayama Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Sakakibara Heart Institute of Okayama Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Sakakibara Heart Institute of Okayama Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hirohata","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Sakakibara Heart Institute of Okayama Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Sakakibara Heart Institute of Okayama Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Sakakibara Heart Institute of Okayama Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.05.015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.08.025"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.04.025"},{"key":"e_1_2_6_5_1","first-page":"234","article-title":"Understanding mitral valve pathology: Three\u2010dimensional transesophageal echocardiography parametric maps","volume":"53","author":"Vrettou AR","year":"2012","journal-title":"Hellenic J 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