{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:16:13Z","timestamp":1776820573450,"version":"3.51.2"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The prenatal diagnosis of coarctation of aorta (CoA) can prove problematic, with relatively high false\u2010positive and false\u2010negative rates. This significantly impacts both prenatal counseling and postnatal management. We sought to evaluate a variety of prenatal echo indices to determine which would best predict neonatal CoA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fetal echocardiograms of those with prenatal diagnosis of <jats:styled-content style=\"fixed-case\">COA<\/jats:styled-content> were analyzed for the following: diameter of cardiac valves, ascending aorta, distal transverse arch, aortic isthmus, and ductus; right (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) and left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) length and end\u2010diastolic area and isthmus\u2013ductal angle (<jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content>). Ratios of <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\"> LV<\/jats:styled-content> area, aortic: pulmonary valve diameter, mitral: tricuspid valve ratio (<jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content> ratio), and isthmus: ductal diameter (<jats:styled-content style=\"fixed-case\">IDD<\/jats:styled-content>) were calculated. These measures were compared between those with CoA after birth (CoA group) and those without (no CoA group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 62 subjects, 27 were in CoA and 35 in no CoA group. CoA group had a significantly smaller mitral valve, <jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content> ratio, <jats:styled-content style=\"fixed-case\">IDD<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> compared to no CoA group. The <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curves for each of these significant measures showed that mitral valve, <jats:styled-content style=\"fixed-case\">IDD<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> had an <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> of 0.72, 0.80, and 0.83, respectively. Multiple variable model using at least two of these measures had 85% sensitivity and 60% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A smaller mitral valve, <jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content> ratio, <jats:styled-content style=\"fixed-case\">IDD<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> are associated with development of neonatal coarctation. In cases with suspected prenatal diagnosis of CoA, careful evaluation of the relation between the isthmus and the ductus arteriosus using <jats:styled-content style=\"fixed-case\">IDD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> may enhance the diagnostic accuracy of fetal echocardiograms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13140","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T05:06:34Z","timestamp":1450155994000},"page":"771-777","source":"Crossref","is-referenced-by-count":42,"title":["Importance of Relationship between Ductus and Isthmus in Fetal Diagnosis of Coarctation of Aorta"],"prefix":"10.1111","volume":"33","author":[{"given":"Benjamin J.","family":"Toole","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Children's Healthcare of Atlanta and Sibley Heart Center Cardiology Emory University School of Medicine Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Children's Healthcare of Atlanta and Sibley Heart Center Cardiology Emory University School of Medicine Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney E.","family":"McCracken","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Children's Healthcare of Atlanta and Sibley Heart Center Cardiology Emory University School of Medicine Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanci","family":"Stauffer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Children's Healthcare of Atlanta and Sibley Heart Center Cardiology Emory University School of Medicine Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William L.","family":"Border","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Children's Healthcare of Atlanta and Sibley Heart Center Cardiology Emory University School of Medicine Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Children's Healthcare of Atlanta and Sibley Heart Center Cardiology Emory University School of Medicine Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00385.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.119032"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.71.1.70"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.1.67"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-993934"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1997.16.2.95"},{"key":"e_1_2_6_9_1","first-page":"428","article-title":"Is antenatal diagnosis of coarctation of the aorta possible?","volume":"100","author":"Stos B","year":"2007","journal-title":"Arch Mal Coeur 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