{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:41:53Z","timestamp":1789994513215,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Ultrasound contrast agents may be used for the assessment of regional wall motion and myocardial perfusion, but are generally considered not suitable for deformation analysis. The aim of our study was to assess the feasibility of deformation imaging on contrast\u2010enhanced images using a novel methodology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We prospectively enrolled 40 patients who underwent stress echocardiography with continuous intravenous infusion of SonoVue for the assessment of myocardial perfusion imaging with flash replenishment technique. We compared longitudinal strain (L\u03b5) values, assessed with a vendor\u2010independent software (2D <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content>), on 68 resting contrast\u2010enhanced and 68 resting noncontrast recordings. Strain analysis on contrast recordings was evaluated in the first cardiac cycles after the flash. Tracking of contrast images was deemed feasible in all subjects and in all views. Contrast administration improved image quality and increased the number of segments used for deformation analysis. L\u03b5 of noncontrast and contrast\u2010enhanced images were statistically different (\u221218.8 \u00b1 4.5% and \u221222.8 \u00b1 5.4%, respectively; P &lt; 0.001), but their correlation was good (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> 0.65, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.42\u20130.78). Patients with resting wall\u2010motion abnormalities showed lower L\u03b5 values on contrast recordings (\u221218.6 \u00b1 6.0% vs. \u221224.2 \u00b1 5.5%, respectively; P &lt; 0.01). Intra\u2010operator and inter\u2010operator reproducibility was good for both noncontrast and contrast images with no statistical differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study shows that deformation analysis on postflash contrast\u2010enhanced images is feasible and reproducible. Therefore, it would be possible to perform a simultaneous evaluation of wall\u2010motion abnormalities, volumes, ejection fraction, perfusion defects, and cardiac deformation on the same contrast recording.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13190","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T07:06:15Z","timestamp":1454310375000},"page":"889-895","source":"Crossref","is-referenced-by-count":9,"title":["Simultaneous Assessment of Myocardial Perfusion, Wall Motion, and Deformation during Myocardial Contrast Echocardiography: A Feasibility Study"],"prefix":"10.1111","volume":"33","author":[{"given":"Giacomo","family":"Zoppellaro","sequence":"first","affiliation":[{"name":"Department of Echocardiography Royal Brompton Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Venneri","sequence":"additional","affiliation":[{"name":"Department of Echocardiography Royal Brompton Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajdeep S.","family":"Khattar","sequence":"additional","affiliation":[{"name":"Department of Echocardiography Royal Brompton Hospital London United Kingdom"},{"name":"Cardiovascular Biomedical Research Unit Royal Brompton Hospital London United Kingdom"},{"name":"National Heart and Lung Institute (NHLI) Imperial College London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Echocardiography Royal Brompton Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxy","family":"Senior","sequence":"additional","affiliation":[{"name":"Department of Echocardiography Royal Brompton Hospital London United Kingdom"},{"name":"Cardiovascular Biomedical Research Unit Royal Brompton Hospital London United Kingdom"},{"name":"National Heart and Lung Institute (NHLI) Imperial College London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jen175"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02863-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.02.015"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.09.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2007.10.014"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.082"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.054"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.08.009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00212-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.01.028"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/AC.69.1.3011340","article-title":"Impact of microbubble contrast on 2D strain quantification","volume":"69","author":"Ejlersen JA","year":"2014","journal-title":"Acta Cardiol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.08.010"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.12.007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.10.008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.02.014"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.13190","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.13190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:34:01Z","timestamp":1696361641000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.13190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/echo.13190"],"URL":"https:\/\/doi.org\/10.1111\/echo.13190","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2]]}}}