{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:32:42Z","timestamp":1789021962468,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,3]],"date-time":"2016-04-03T00:00:00Z","timestamp":1459641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5U01HL105561\u201002"],"award-info":[{"award-number":["5U01HL105561\u201002"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1U01HL10556\u201001"],"award-info":[{"award-number":["1U01HL10556\u201001"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) transient ischemic dilatation (<jats:styled-content style=\"fixed-case\">TID<\/jats:styled-content>) is not clear how it relates to inducible myocardial ischemia during stress echocardiography (<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Eighty\u2010eight <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>s were examined from the site certification phase of the <jats:styled-content style=\"fixed-case\">ISCHEMIA<\/jats:styled-content> Trial. <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> end\u2010diastolic volume (<jats:styled-content style=\"fixed-case\">EDV<\/jats:styled-content>) and end\u2010systolic volume (<jats:styled-content style=\"fixed-case\">ESV<\/jats:styled-content>) were measured at rest and peak stages and the percent change calculated. Moderate or greater ischemia was defined as \u22653 segments with stress\u2010induced severe hypokinesis or akinesis. Optimum cut points in stress\u2010induced percent <jats:styled-content style=\"fixed-case\">EDV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ESV<\/jats:styled-content> change that identified moderate or greater myocardial ischemia were analyzed. Analysis from percentage distribution identified a &gt; 13% <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> volume increase in <jats:styled-content style=\"fixed-case\">EDV<\/jats:styled-content> or a &gt; 9% <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> volume increase in <jats:styled-content style=\"fixed-case\">ESV<\/jats:styled-content> as the optimum cutoff points for moderate or greater ischemia. Using these definitions for <jats:styled-content style=\"fixed-case\">TID<\/jats:styled-content>, there were 27 (31%) with <jats:styled-content style=\"fixed-case\">TID<jats:sub>ESV<\/jats:sub><\/jats:styled-content> and 12 (14%) with <jats:styled-content style=\"fixed-case\">TID<jats:sub>EDV<\/jats:sub><\/jats:styled-content>. By logistic regression analysis and receiver operating characteristic curves, the percent change in <jats:styled-content style=\"fixed-case\">ESV<\/jats:styled-content> had a stronger association with moderate or greater myocardial ischemia than that of <jats:styled-content style=\"fixed-case\">EDV<\/jats:styled-content> change. Compared to those without <jats:styled-content style=\"fixed-case\">TID<jats:sub>ESV<\/jats:sub><\/jats:styled-content>, cases with <jats:styled-content style=\"fixed-case\">TID<jats:sub>ESV<\/jats:sub><\/jats:styled-content> had larger extent of inducible wall\u2010motion abnormalities, lower peak stress <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>, and higher likelihood of moderate or grater ischemia. For moderate or greater myocardial ischemia detection, <jats:styled-content style=\"fixed-case\">TID<jats:sub>ESV<\/jats:sub><\/jats:styled-content> had a sensitivity of 46%, specificity of 83%, positive predictive value of 70%, and negative predictive value of 64%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transient ischemic dilatation by <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> is a marker of extensive myocardial ischemia and can be used as an additional marker of higher risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13222","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T04:03:08Z","timestamp":1459742588000},"page":"1202-1208","source":"Crossref","is-referenced-by-count":13,"title":["Transient Ischemic Dilatation during Stress Echocardiography: An Additional Marker of Significant Myocardial Ischemia"],"prefix":"10.1111","volume":"33","author":[{"given":"Akihisa","family":"Kataoka","sequence":"first","affiliation":[{"name":"Cardiac Ultrasound Laboratory Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Scherrer\u2010Crosbie","sequence":"additional","affiliation":[{"name":"Cardiac Ultrasound Laboratory Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxy","family":"Senior","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Division of Cardiology National Heart and Lung Institute and Imperial College London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Garceau","sequence":"additional","affiliation":[{"name":"Department of Medicine Montreal Heart Institute Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Valbuena","sequence":"additional","affiliation":[{"name":"Department of Cardiology La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"\u010celutkien\u0117","sequence":"additional","affiliation":[{"name":"Center of Cardiology and Angiology Vilnius University Hospital Santariskiu Clinic Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Hastings","sequence":"additional","affiliation":[{"name":"Division of Cardiology V.A. 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