{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:37:39Z","timestamp":1788244659831,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T00:00:00Z","timestamp":1462320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Right ventricular (RV) effects of long\u2010term use of anabolic\u2013androgenic steroids (AAS) are not clearly known. The aim of this study was to assess RV systolic functions by two\u2010dimensional speckle tracking echocardiography (2DSTE) in AAS user and nonuser bodybuilders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 33 competitive male bodybuilders (15 AAS users, 18 AAS nonusers) were assessed. To assess RV systolic functions, all participants underwent standard two\u2010dimensional and Doppler echocardiography, and 2DSTE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Interventricular septal thickness, left ventricle posterior wall thickness, relative wall thickness, and left ventricle mass index were significantly higher in AAS users than nonusers. While standard diastolic parameters were not statistically different between the groups, tissue Doppler parameters including RV E\u2032 and E\u2032\/A\u2032 were lower in AAS users than nonusers (10.1 \u00b1 2.0 vs. 12.7 \u00b1 2.1; P = 0.001, 1.1 \u00b1 0.1 vs. 1.5 \u00b1 0.4; P = 0.009, respectively). Tricuspid annular plane systolic excursion, RV fractional area change, and RV S\u2032 were in normal ranges. However, RV S\u2032 was found to be lower in users than nonusers (12.2 \u00b1 2.2 vs. 14.6 \u00b1 2.8, P = 0.011). RV free wall longitudinal strain and strain rate were decreased in AAS users in comparison with nonusers (\u221220.2 \u00b1 3.1 vs. \u221223.3 \u00b1 3.5; P = 0.012, \u22123.2 \u00b1 0.1 vs. \u22123.4 \u00b1 0.1; P = 0.022, respectively). In addition, there were good correlations between 2DSTE parameters and RV S\u2032, E\u2032, and E\u2032\/A\u2032.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite normal standard systolic echo parameters, peak systolic RV free wall strain and strain rate were reduced in AAS user bodybuilders in comparison with nonusers. Strain and strain rate by 2DSTE may be useful for early determination of subclinical RV dysfunction in AAS user bodybuilders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13243","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T17:09:01Z","timestamp":1462381741000},"page":"1178-1185","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of Right Ventricle Systolic Function between Long\u2010Term Anabolic\u2013Androgenic Steroid User and Nonuser Bodybuilder Athletes: A Study of Two\u2010Dimensional Speckle Tracking Echocardiography"],"prefix":"10.1111","volume":"33","author":[{"given":"Elnur","family":"Alizade","sequence":"first","affiliation":[{"name":"Cardiology Department Kartal Kosuyolu Heart Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Avci","sequence":"additional","affiliation":[{"name":"Cardiology Department Kartal Kosuyolu Heart Research and 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