{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:55:41Z","timestamp":1762376141152},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T00:00:00Z","timestamp":1474934400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Aim of the study was to determine the influence of right heart volume overload in children with atrial septal defect (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>) on right ventricular outflow tract (<jats:styled-content style=\"fixed-case\">RVOT<\/jats:styled-content>) variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was conducted in 115 children (age range: 2\u00a0days\u201318.1\u00a0years) with a moderate to large <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>. We determined effects of age, body length (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>), body weight (<jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content>), and body surface area (<jats:styled-content style=\"fixed-case\">BSA<\/jats:styled-content>) on the variables <jats:styled-content style=\"fixed-case\">RVOT<\/jats:styled-content> diameter, <jats:styled-content style=\"fixed-case\">RVOT<\/jats:styled-content> velocity time integral (<jats:styled-content style=\"fixed-case\">VTI<\/jats:styled-content>), and <jats:styled-content style=\"fixed-case\">RVOT<\/jats:styled-content> systolic excursion (<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>), and tested the predictive value of published normal values for age, <jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> BL<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">BSA<\/jats:styled-content> in our <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our pediatric <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> patients, the age\u2010specific <jats:styled-content style=\"fixed-case\">RVOT<\/jats:styled-content> diameter (z\u2010score: +2.2, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.0\u20132.4, P\u00a0&lt;\u00a00.001) was significantly increased compared to normal values with 54% of our <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> patients having a z\u2010score &gt;2.0. The age\u2010specific <jats:styled-content style=\"fixed-case\">RVOT VTI<\/jats:styled-content> z\u2010score (z\u2010score: +3.6, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 3.2\u20133.9, P\u00a0&lt;\u00a00.001) was significantly increased compared to normal values with 81% of our <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> patients having a z\u2010score &gt;2.0. The age\u2010specific <jats:styled-content style=\"fixed-case\">RVOT SE<\/jats:styled-content> z\u2010score was not increased but slightly lower compared to normal values (z\u2010score: \u22120.5, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22120.7 to \u22120.3, P\u00a0&lt;\u00a00.001) with 3% of our <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> patients having a z\u2010score &gt;2.0 while 12% of the patients had a z\u2010score &lt;\u22122.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our study population, we show the <jats:styled-content style=\"fixed-case\">RVOT VTI<\/jats:styled-content> and diameter to be relevant predictors in identifying an enlarged <jats:styled-content style=\"fixed-case\">RVOT<\/jats:styled-content> size and flow in children with moderate to large <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13246","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T04:18:06Z","timestamp":1475036286000},"page":"1389-1396","source":"Crossref","is-referenced-by-count":7,"title":["Right Ventricular Outflow Tract (<scp>RVOT<\/scp>) Changes in Children with an Atrial Septal Defect: Focus on <scp>RVOT<\/scp> Velocity Time Integral, <scp>RVOT<\/scp> Diameter, and <scp>RVOT<\/scp> Systolic Excursion"],"prefix":"10.1111","volume":"33","author":[{"given":"Martin","family":"Koestenberger","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Medical University Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Ravekes","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Johns Hopkins University School of Medicine Baltimore 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