{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:02:02Z","timestamp":1760608922353,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,24]],"date-time":"2016-04-24T00:00:00Z","timestamp":1461456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Breast cancer patients exposed to doses of radiation after radiotherapy could develop toxicity to lung. Lung ultrasound (<jats:styled-content style=\"fixed-case\">LUS<\/jats:styled-content>) is able to detect interstitial lung disease by the evaluation of B\u2010lines. The aim of our study was to assess the number of B\u2010lines to diagnose lung involvement after chest radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We measured <jats:styled-content style=\"fixed-case\">LUS<\/jats:styled-content> B\u2010lines in the treated and contralateral lung of 20 breast cancer patients, 1\u20133 months after the end of radiotherapy and 1 year after previous <jats:styled-content style=\"fixed-case\">LUS<\/jats:styled-content>. The sum of the B\u2010lines number in the 72 sites on anterior and posterior chest yielded a global B\u2010lines score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>B\u2010lines were more numerous in treated (median: 21; 1st\u20133rd quartiles: 11\u201331) versus untreated hemithorax (median: 3; 1st\u20133rd quartiles: 1\u20135) in both examination at T<jats:sub>1\u20133 months<\/jats:sub> (Kolmogorov\u2013Smirnov test P &lt; 0.001) and T<jats:sub>1 year<\/jats:sub> (median: 21; 1st\u20133rd quartiles: 12\u201328 vs. median: 4; 1st\u20133rd quartiles: 1\u201310; Kolmogorov\u2013Smirnov test P &lt; 0.01). Within the treated hemithorax, B\u2010lines were more frequent in the anterior than in the posterior chest in both examination at T<jats:sub>1\u20133 months<\/jats:sub> (Kolmogorov\u2013Smirnov test: P &lt; 0.0001) and T<jats:sub>1 year<\/jats:sub> (Kolmogorov\u2013Smirnov test: P &lt; 0.01). Abnormal scores (B\u2010lines&gt;5) were present in 17\/20 treated versus 7\/20 untreated hemithoraxes (85.0 vs. 35.0%, P &lt; 0.01) in the first <jats:styled-content style=\"fixed-case\">LUS<\/jats:styled-content> and likewise in 16\/17 treated versus 7\/17 in untreated hemithorax (94.1% vs. 41.2%, P &lt; 0.01) after 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among women receiving radiotherapy after breast cancer, B\u2010lines are present predominantly in the irradiated lung. These data suggest that B\u2010lines by <jats:styled-content style=\"fixed-case\">LUS<\/jats:styled-content> could provide, at a subclinical stage, a radiation\u2010free biomarker of radiotherapy\u2010induced lung damage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13249","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T03:48:39Z","timestamp":1461556119000},"page":"1374-1380","source":"Crossref","is-referenced-by-count":6,"title":["The Potential Role of Lung Ultrasound B\u2010Lines for Detection of Lung Radio\u2010Induced Toxicity in Breast Cancer Patients after Radiation Therapy"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-7097","authenticated-orcid":false,"given":"Maria Fonte","family":"Petruzzelli","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology \u201cPerrino Hospital,\u201d Brindisi Italy"},{"name":"Department of Interdisciplinary Medicine Section of Diagnostic Imaging and Radiotherapy University \u201cAldo Moro,\u201d Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Pia","family":"Vasti","sequence":"additional","affiliation":[{"name":"Oncologic Ultrasonography Unit \u201cF. 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