{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T09:07:42Z","timestamp":1788685662159,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T00:00:00Z","timestamp":1462406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate ventricular diastolic dysfunction, inter\u2010 and intraatrial conduction delay, and P\u2010wave dispersion in pediatric patients with subclinical hypothyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study comprised a total of 30 pediatric patients with subclinical hypothyroidism (<jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>) (mean age 7.8 \u00b1 3.2 years) and 30 healthy children (mean age 8.4 \u00b1 3.6 years) as the control group. A <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content> diagnosis was made in the event of increased serum thyroid\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>) and decreased serum free triiodothyronine (T<jats:sub>3<\/jats:sub>) and free thyroxine (T<jats:sub>4<\/jats:sub>) concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Conventional Doppler imaging (<jats:styled-content style=\"fixed-case\">TDI<\/jats:styled-content>) showed low mitral early diastolic E\u2010wave velocity and E\/A ratio (P &lt; 0.001) and significantly higher mitral late diastolic A\u2010wave velocity (P = 0.001) in hypothyroidism patients. Moreover, patients with hypothyroidism had significantly lower left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) septal E<jats:sub>m<\/jats:sub> velocity and E<jats:sub>m<\/jats:sub>\/A<jats:sub>m<\/jats:sub> ratios compared with the control group (P &lt; 0.001), whereas A<jats:sub>m<\/jats:sub> velocity was higher in hypothyroidism patients (P = 0.018). <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> lateral E<jats:sub>m<\/jats:sub> velocity and E<jats:sub>m<\/jats:sub>\/A<jats:sub>m<\/jats:sub> ratio were significantly lower in patients with hypothyroidism compared with the control group (P &lt; 0.001). With regard to atrial electromechanical conduction, atrial electromechanical delay (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>) lateral, <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> septum, <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> tricuspid, and each of interatrial and intraatrial conduction delay were significantly prolonged in hypothyroidism patients as compared with the control group (P &lt; 0.001, P &lt; 0.001, P = 0.023, P = 0.002, and P = 0.003, respectively). P\u2010wave dispersion was significantly different in the pediatric patients with hypothyroidism (P &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated atrial electromechanical conduction delay, abnormal P\u2010wave dispersion, and ventricle diastolic dysfunction in pediatric patients with hypothyroidism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13255","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T09:55:38Z","timestamp":1462442138000},"page":"1397-1401","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of P\u2010Wave Dispersion, Diastolic Function, and Atrial Electromechanical Conduction in Pediatric Patients with Subclinical Hypothyroidism"],"prefix":"10.1111","volume":"33","author":[{"given":"Ahmet","family":"Irdem","sequence":"first","affiliation":[{"name":"Pediatric Cardiology Department Okmeydani Education and Training Hospital Istanbul 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