{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:21:42Z","timestamp":1780550502225,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:00:00Z","timestamp":1469577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary arterial hypertension (<jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>) is characterized by elevated mean pulmonary arterial pressure with abnormal right ventricular (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) pressure overload that may alter left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) function. The aim of this study was to assess the impact of <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> pressure overload on <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> function in <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content> patients using two\u2010dimensional (2D) speckle tracking strain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study enrolled 37 group 1 <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content> patients and 38 age\u2010 and gender\u2010matched healthy controls. <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> longitudinal and radial 2D strains were measured with and without including the ventricular septum. Six\u2010minute walk test (6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content>) and brain natriuretic peptide (<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>) levels were also obtained in patients with <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of patients was 46.4 \u00b1 14.8 years, 76% women, and 16 patients (43%) had schistosomiasis. Sixteen patients (43%) were in <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> class <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> under specific treatment for <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>. The overall 6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> distance was 441 meters, and the <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> levels were 80 pg\/mL. Patients with <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content> more commonly presented with <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> diastolic dysfunction and impairment of <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> function when compared to controls. <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> global longitudinal and radial strains were lower in patients than in controls (\u221217.9 \u00b1 2.8 vs. \u221220.5 \u00b1 1.9; P &lt; 0.001 and 30.8 \u00b1 10.5 vs. 49.8 \u00b1 15.4; P &lt; 0.001, respectively). After excluding septal values, <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> longitudinal and radial strains remained lower in patients than in controls. The independent factors associated with global <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> longitudinal strain were <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> ejection fraction, <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> fractional area change, and tricuspid annular systolic motion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed impaired <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> contractility in patients with <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content> assessed by speckle tracking strain, irrespective of ventricular septal involvement. Global <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> longitudinal strain was associated independently with <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> fractional area change and tricuspid annular systolic motion, after adjustment for <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> ejection fraction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13267","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T05:24:51Z","timestamp":1469597091000},"page":"1326-1334","source":"Crossref","is-referenced-by-count":18,"title":["Left Ventricular Function in Patients with Pulmonary Arterial Hypertension: The Role of Two\u2010Dimensional Speckle Tracking Strain"],"prefix":"10.1111","volume":"33","author":[{"given":"Ricardo","family":"de Amorim Corr\u00eaa","sequence":"first","affiliation":[{"name":"Post\u2010Graduate Program in Infectious Diseases and Tropical Medicine School of Medicine Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Brito","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Program in Infectious Diseases and Tropical Medicine School of Medicine Federal University of Minas Gerais Belo Horizonte Brazil"},{"name":"Ecocenter Hospital Socor Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia M.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Ecocenter Hospital Socor Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Augusto A.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Ecocenter Hospital Socor Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u00eds Soares","family":"Carvalho","sequence":"additional","affiliation":[{"name":"School of Medicine Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele Campos","family":"Barreto","sequence":"additional","affiliation":[{"name":"School of Medicine Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico Thadeu A. 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