{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T06:15:14Z","timestamp":1772259314540,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:00:00Z","timestamp":1466985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Background<\/jats:title>The goal of this study was to determine changes in left atrial (LA<\/jats:styled-content>) function with two\u2010dimensional speckle tracking echocardiography (2DSTE<\/jats:styled-content>) and real\u2010time full\u2010volume three\u2010dimensional echocardiography (RT<\/jats:styled-content>3DE<\/jats:styled-content>) after percutaneous mitral valve repair with the MitraClip system. Furthermore, we investigated whether baseline and\/or changes in LA<\/jats:styled-content> function after MitraClip repair had any impact on prognosis.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 25 consecutive patients (age: 57\u00b112\u00a0years, 76% male) with moderate\u2010to\u2010severe or severe mitral regurgitation (MR<\/jats:styled-content>) were included. Patients underwent 2DSTE<\/jats:styled-content> and RT<\/jats:styled-content>3DE<\/jats:styled-content> before the clip implantation and after the 12\u2010month follow\u2010up. Prognostic data were also recorded via the use of telephone calls and follow\u2010up visits for 12\u00a0months after the procedure.<\/jats:p><\/jats:sec>Results<\/jats:title>Compared with the baseline, the LA<\/jats:styled-content> reservoir strain (LA<\/jats:styled-content>\u2010Res) (7.66\u00b14.3% vs 11.15\u00b17.5%, P<\/jats:italic><.001) and LA<\/jats:styled-content> contraction strain (LA<\/jats:styled-content>\u2010Pump) (4.64\u00b14.3% vs 7.63\u00b15.8%, P<\/jats:italic>=.001) improved significantly after MitraClip repair; significant improvements were also seen in three\u2010dimensional (3D) minimum LA<\/jats:styled-content> volume index (LAV<\/jats:styled-content> min) and maximum LA<\/jats:styled-content> volume index (LAV<\/jats:styled-content> max). On the other hand, conventional LA<\/jats:styled-content> indices did not change. In total, eleven major adverse cardiac events (MACE<\/jats:styled-content>) were observed at the 1\u2010year follow\u2010up. In univariate analyses, the preprocedural echocardiographic parameters that were associated with the MACE<\/jats:styled-content> within 1\u00a0year after MitraClip repair were 3D\u2010LAV<\/jats:styled-content> min and LA<\/jats:styled-content>\u2010Res. Furthermore, these indices significantly correlated with improved functional parameters and MR<\/jats:styled-content> reduction.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In conclusion, a successful MitraClip procedure can reverse the process of LA<\/jats:styled-content> remodeling within 12\u00a0months, and this can be detected by 2DSTE<\/jats:styled-content> and RT<\/jats:styled-content>3DE<\/jats:styled-content>. Also, patients with preprocedural lower LA<\/jats:styled-content>\u2010Res and higher 3D\u2010LAV<\/jats:styled-content> min had the worst prognoses at the 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13288","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T03:08:52Z","timestamp":1467169732000},"page":"1504-1511","source":"Crossref","is-referenced-by-count":37,"title":["Left atrial remodeling in patients undergoing percutaneous mitral valve repair with the MitraClip system: an advanced echocardiography study"],"prefix":"10.1111","volume":"33","author":[{"given":"Cuneyt","family":"Toprak","sequence":"first","affiliation":[{"name":"Department of Cardiology Kosuyolu Kartal Heart Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokhan","family":"Kahveci","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kosuyolu Kartal Heart Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alev","family":"Kilicgedik","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kosuyolu Kartal Heart Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcuk","family":"Pala","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kosuyolu Kartal Heart Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cevat","family":"Kirma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kosuyolu Kartal Heart Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Mustafa","family":"Tabakci","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kosuyolu Kartal Heart Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Inanir","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kosuyolu Kartal Heart Training and Research Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Metin","family":"Esen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Memorial Sisli Hospital Istanbul 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