{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:09:40Z","timestamp":1776204580565,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T00:00:00Z","timestamp":1471651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008571","name":"School of Medicine, Southern Illinois University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Aims<\/jats:title>Reduced global longitudinal systolic strain (GLS<\/jats:styled-content>) is a common finding in end\u2010stage renal disease (ESRD<\/jats:styled-content>) patients with normal ejection fraction (EF<\/jats:styled-content>), and GLS<\/jats:styled-content> is a stronger predictor of mortality than EF<\/jats:styled-content>. We sought to determine what factors may be responsible for the decreased strain in this population.<\/jats:p><\/jats:sec>Methods and Results<\/jats:title>The study group was comprised of 139 renal transplant candidates with a normal EF<\/jats:styled-content> who had echocardiography with assessment of GLS<\/jats:styled-content> and basal longitudinal systolic strain (BLS<\/jats:styled-content>). A GLS<\/jats:styled-content> of less than \u221218 and a BLS<\/jats:styled-content> less than \u221217 were defined as abnormal. Logistic regression was used to determine variables associated with abnormal GLS<\/jats:styled-content> and BLS<\/jats:styled-content>. Of the 139 patients, 49% had abnormal GLS<\/jats:styled-content> and 70% had abnormal BLS<\/jats:styled-content>. The univariate predictors of abnormal GLS<\/jats:styled-content> (P<\/jats:italic><.05) were low\u2010normal EF<\/jats:styled-content>, increased interventricular septal thickness (IVS<\/jats:styled-content>), diabetes, and dihydropyridine calcium channel blocker use. The univariate predictors of abnormal BLS<\/jats:styled-content> (P<\/jats:italic><.05) were elevated systolic blood pressure, elevated diastolic blood pressure, elevated heart rate, decreased EF<\/jats:styled-content>, increased IVS<\/jats:styled-content>, increased left ventricular posterior wall thickness (LVPW<\/jats:styled-content>), increased left ventricular mass index, regular dialysis, and clonidine use. On multivariate analysis, low\u2010normal EF<\/jats:styled-content> (P<\/jats:italic><.001), increased IVS<\/jats:styled-content> (P<\/jats:italic>=.024), and diabetes (P<\/jats:italic>=.042) were independent predictors of abnormal GLS<\/jats:styled-content>, while increased DBP<\/jats:styled-content> (P<\/jats:italic>=.018), increased LVPW<\/jats:styled-content> (P<\/jats:italic>=.001), and regular dialysis (P<\/jats:italic>=.006) were independent predictors of abnormal BLS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Clinical variables and co\u2010findings beyond EF<\/jats:styled-content> are associated with abnormal strain measurements and may partially explain the large incidence of abnormal strain in renal transplant candidates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13307","type":"journal-article","created":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T08:02:47Z","timestamp":1471680167000},"page":"1676-1682","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence, etiology, and clinical implications of reduced longitudinal systolic strain in renal transplant candidates"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-5682","authenticated-orcid":false,"given":"Isaac B.","family":"Rhea","sequence":"first","affiliation":[{"name":"University Hospitals Case Medical Center Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Medicine IU Health Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Sawada","sequence":"additional","affiliation":[{"name":"Krannert Institute of Cardiology IU Health Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey","family":"Feigenbaum","sequence":"additional","affiliation":[{"name":"Krannert Institute of Cardiology IU Health Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,20]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Annual Data Report: Atlas of Chronic Kidney Disease and End\u2010Stage Renal Disease in the United States, National Institute of Health","author":"U.S. Renal Data System. 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