{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:07:51Z","timestamp":1767006471412},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T00:00:00Z","timestamp":1470960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The energy loss coefficient (<jats:styled-content style=\"fixed-case\">ELC<\/jats:styled-content>o) has been suggested as a more accurate indicator of aortic stenosis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) severity as compared to transthoracic echocardiography (<jats:styled-content style=\"fixed-case\">TTE<\/jats:styled-content>) aortic valve area (<jats:styled-content style=\"fixed-case\">AVA<\/jats:styled-content>). There are little data regarding the optimal location for aortic area (Aa) measurement needed for <jats:styled-content style=\"fixed-case\">ELC<\/jats:styled-content>o calculation and the agreement of <jats:styled-content style=\"fixed-case\">ELC<\/jats:styled-content>o with direct anatomical <jats:styled-content style=\"fixed-case\">AVA<\/jats:styled-content> measurement. The aim of this study was to determine the optimal site of Aa measurement for calculation of the <jats:styled-content style=\"fixed-case\">ELC<\/jats:styled-content>o, using cardiac computed tomography angiography (<jats:styled-content style=\"fixed-case\">CCTA<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">AVA<\/jats:styled-content> planimetry as the reference standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 69 patients with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> who underwent both <jats:styled-content style=\"fixed-case\">CCTA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TTE<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">ELC<\/jats:styled-content>o and <jats:styled-content style=\"fixed-case\">CCTA<\/jats:styled-content> planimetry <jats:styled-content style=\"fixed-case\">AVA<\/jats:styled-content> were compared using multiple sites for <jats:styled-content style=\"fixed-case\">CCTA<\/jats:styled-content> Aa measurement (sinus, sinotubular junction, or ascending aorta).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CCTA AVA<\/jats:styled-content> was 0.96\u00b10.46\u00a0cm<jats:sup>2<\/jats:sup>. <jats:styled-content style=\"fixed-case\">ELC<\/jats:styled-content>o was 0.95\u00b10.43\u00a0cm<jats:sup>2<\/jats:sup> using sinotubular junction Aa, 0.92\u00b10.41\u00a0cm<jats:sup>2<\/jats:sup> using sinus Aa, and 0.91\u00b10.4\u00a0cm<jats:sup>2<\/jats:sup> using the ascending aorta (<jats:italic>P<\/jats:italic>=.84, <jats:italic>P<\/jats:italic>=.13, and <jats:italic>P<\/jats:italic>=.08 compared to <jats:styled-content style=\"fixed-case\">CCTA AVA<\/jats:styled-content>). There was good agreement between <jats:styled-content style=\"fixed-case\">CCTA AVA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ELC<\/jats:styled-content>o using all Aa locations (0.89\u20130.90). On subgroup analysis of 16 patients most likely to be affected by pressure recovery (aortic diameter&lt;3\u00a0cm and <jats:styled-content style=\"fixed-case\">AVA<\/jats:styled-content> \u22651\u00a0cm<jats:sup>2<\/jats:sup>), <jats:styled-content style=\"fixed-case\">ELC<\/jats:styled-content>o using the sinotubular junction Aa showed the best agreement with <jats:styled-content style=\"fixed-case\">CCTA AVA<\/jats:styled-content> as compared to the other Aa locations (0.84 vs 0.75\u20130.77).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ELC<\/jats:styled-content>o using Aa measurement at the sinotubular junction showed the best agreement with <jats:styled-content style=\"fixed-case\">CCTA AVA<\/jats:styled-content>. We therefore recommend using the sinotubular junction Aa for <jats:styled-content style=\"fixed-case\">ELC<\/jats:styled-content>o calculation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13331","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T05:17:08Z","timestamp":1470979028000},"page":"1649-1655","source":"Crossref","is-referenced-by-count":3,"title":["The effect of aortic area measurement site on the energy loss coefficient: a comparison between echocardiography and cardiac computed tomography angiography in patients with aortic stenosis"],"prefix":"10.1111","volume":"33","author":[{"given":"Dotan","family":"Yaari","sequence":"first","affiliation":[{"name":"Ruth and Bruce Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronen","family":"Rubinshtein","sequence":"additional","affiliation":[{"name":"Ruth and Bruce Rappaport Faculty of Medicine 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