{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:06:50Z","timestamp":1791338810678,"version":"4.3.1"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>The role of echocardiography in improving the selection of patients who will benefit from cardiac resynchronization therapy (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>) remains a source of debate. Although previous landmark reports have demonstrated a link between mechanical dyssynchrony, assessed by delays between left ventricle (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) walls and response to <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>, the predictive value of these findings has not yet been confirmed in multicenter trials. Indeed, recent studies demonstrated that the classical assessment of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> mechanical dyssynchrony using delay between walls by echocardiography depends not only on <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> electrical activation delay (electrical dyssynchrony), but also on abnormalities in regional contractility of the <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> and\/or loading conditions, which do not represent an appropriate target for <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>. Recent reports highlighted the value of new indices of electromechanical dyssynchrony obtained by echocardiography, to predict <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> response and outcome after <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> including septal flash, left bundle branch block\u2014typical pattern by longitudinal strain, apical rocking, septal strain patterns, and systolic stretch index. This was achieved using a mechanistic approach, based on the contractile consequences of electrical dyssynchrony. These indices are rarely found in patients with narrow <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> (&lt;120\u00a0ms), whereas their frequency rises in patients with an increase in <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> duration (&gt;120\u00a0ms). Theses indices should improve candidate selection for <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> in clinical practice, especially for patients in whom the benefit of <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> remains uncertain, for example, patients with intermediate <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> width (120\u2013150\u00a0ms).<\/jats:p>","DOI":"10.1111\/echo.13334","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T04:47:34Z","timestamp":1472186854000},"page":"1745-1752","source":"Crossref","is-referenced-by-count":22,"title":["Role of echocardiography before cardiac resynchronization therapy: new advances and current developments"],"prefix":"10.1111","volume":"33","author":[{"given":"Sylvestre","family":"Marechaux","sequence":"first","affiliation":[{"name":"Lille North of France University\/Catholic University Hospital\/Catholic School of Medicine Cardiology 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