{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T19:50:28Z","timestamp":1771962628191,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T00:00:00Z","timestamp":1473033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL07915"],"award-info":[{"award-number":["HL07915"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01HL098153"],"award-info":[{"award-number":["U01HL098153"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01HL125521"],"award-info":[{"award-number":["K01HL125521"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Tricuspid annular plane systolic excursion (<jats:styled-content style=\"fixed-case\">TAPSE<\/jats:styled-content>) is a reproducible measure of right ventricular systolic function. We sought to determine the reliability of <jats:styled-content style=\"fixed-case\">TAPSE<\/jats:styled-content> measurements, to evaluate <jats:styled-content style=\"fixed-case\">TAPSE<\/jats:styled-content> in patients with hypoplastic left heart syndrome (<jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content>) relative to normal values, and to correlate values of <jats:styled-content style=\"fixed-case\">TAPSE<\/jats:styled-content> with measures of exercise performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Tricuspid annular plane systolic excursion measurements were performed off\u2010line in the cohort of patients with single right ventricle anatomy who had been enrolled in the Sildenafil After Fontan Operation clinical trial. These values were converted to <jats:italic>z<\/jats:italic>\u2010scores using age\u2010specific means and standard deviations according to published reference values. Reproducibility of measurements was assessed using the coefficient of variation between two readers. Comparisons between echo measurements and exercise outcomes were assessed using Pearson correlation coefficients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010four echocardiograms from 11 subjects were included in this analysis. The median age of included subjects was 13\u00a0years (range 12\u201317). The coefficient of variation for <jats:styled-content style=\"fixed-case\">TAPSE<\/jats:styled-content> measurements was 5.0%. <jats:styled-content style=\"fixed-case\">TAPSE<\/jats:styled-content> was significantly diminished relative to reference values, with a median <jats:italic>z<\/jats:italic>\u2010score of \u22127.6. <jats:styled-content style=\"fixed-case\">TAPSE<\/jats:styled-content> values correlated with both maximal oxygen consumption (<jats:italic>R<\/jats:italic>=.64; <jats:italic>P<\/jats:italic>=.033) and oxygen consumption at the anaerobic threshold (<jats:italic>R<\/jats:italic>=.73, <jats:italic>P<\/jats:italic>=.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this small sample of children with <jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TAPSE<\/jats:styled-content> was reproducible, substantially lower than reference values, and correlated well with measures of exercise performance. Further studies are needed to evaluate these findings in a larger cohort and in a longitudinal manner.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13348","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T04:33:23Z","timestamp":1473136403000},"page":"1897-1902","source":"Crossref","is-referenced-by-count":12,"title":["Tricuspid annular plane systolic excursion correlates with exercise capacity in a cohort of patients with hypoplastic left heart syndrome after Fontan operation"],"prefix":"10.1111","volume":"33","author":[{"given":"David J.","family":"Goldberg","sequence":"first","affiliation":[{"name":"The Cardiac Center The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"},{"name":"Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"French","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania"},{"name":"Cardiovascular Institute Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita L.","family":"Szwast","sequence":"additional","affiliation":[{"name":"The Cardiac Center The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"},{"name":"Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"McBride","sequence":"additional","affiliation":[{"name":"The Cardiac Center The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Paridon","sequence":"additional","affiliation":[{"name":"The Cardiac Center The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"},{"name":"Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Rychik","sequence":"additional","affiliation":[{"name":"The Cardiac Center The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"},{"name":"Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mercer\u2010Rosa","sequence":"additional","affiliation":[{"name":"The Cardiac Center The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"},{"name":"Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia 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