{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:58:01Z","timestamp":1790744281250,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T00:00:00Z","timestamp":1473206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac amyloidosis results in increased left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) wall thickness and diastolic dysfunction (<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>). Strain measurements using velocity vector imaging (<jats:styled-content style=\"fixed-case\">VVI<\/jats:styled-content>) may further characterize myocardial dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 43 <jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content> amyloidosis patients were compared to age\u2010matched normals and hypertensive patients (<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>). Subgroup analysis within the amyloid group was performed based on <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> wall thickness (\u226414\u00a0mm, &gt;14\u00a0mm) and diastolic dysfunction (<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>) (Group 1: normal and impaired relaxation, Group 2: pseudonormal, Group 3: restrictive). <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> strain (longitudinal, circumferential, and radial strain (S) and strain rate [Sr]) were measured using velocity vector imaging (<jats:styled-content style=\"fixed-case\">VVI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> wall thickness and <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> were observed in the amyloid group. Global longitudinal (\u221213.9\u00b14.1% vs \u221216.7\u00b13.8%; <jats:italic>P<\/jats:italic>=.002) and radial (27.4\u00b113.4% vs 38.8\u00b115.7%; <jats:italic>P<\/jats:italic>&lt;.001) strain were lower in the amyloid group vs normal controls, while circumferential strain was similar. Segmental analysis demonstrated reduced mid\u2010 and basal segmental strain with relative sparing of apical segments in the amyloid group. Reduced longitudinal and radial strain, with preserved circumferential strain, were observed in patients with wall thickness &gt;14\u00a0mm; however, circumferential strain was also altered when severe <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> (restrictive filling) was present.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduction in longitudinal and radial S and Sr was evident using <jats:styled-content style=\"fixed-case\">VVI<\/jats:styled-content> strain analysis in amyloidosis, with segmental heterogeneity in longitudinal S. There was relative preservation of circumferential strain, which was reduced only in patients with severe <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13355","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T16:38:20Z","timestamp":1473266300000},"page":"1844-1853","source":"Crossref","is-referenced-by-count":13,"title":["Alterations in regional myocardial deformation assessed by strain imaging in cardiac amyloidosis"],"prefix":"10.1111","volume":"33","author":[{"given":"Queenie","family":"Lo","sequence":"first","affiliation":[{"name":"University of New South Wales  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Haluska","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital University of Queensland  Brisbane Qld 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