{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:27Z","timestamp":1787014107804,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T00:00:00Z","timestamp":1473033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2016,12]]},"abstract":"\n Objective<\/jats:title>\n \n To identify echocardiographic factors that correlate with pulmonary hypertension (\n PH<\/jats:styled-content>\n ) in adults with ostium secundum atrial septal defect (\n ASD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Between November 2009 and November 2013, 92 adults with\n ASD<\/jats:styled-content>\n were studied. All had clinical history and transthoracic echocardiogram.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirty\u2010nine percent of patients had severe\n PH<\/jats:styled-content>\n defined as systolic pulmonary artery pressure (\n sPAP<\/jats:styled-content>\n ) of 70\u00a0mm Hg or more. The size of\n ASD<\/jats:styled-content>\n (31.84\u00b18.21\u00a0mm) and a right\u2010sided tricuspid inflow E\u2010wave to tissue Doppler e\u2032\u2010wave ratio >6.2 correlated with severe\n PH<\/jats:styled-content>\n with\n AUC<\/jats:styled-content>\n of 0.704 (\n CI<\/jats:styled-content>\n 95%=0.59 to 0.818,\n P<\/jats:italic>\n <.001) and 0.65 (\n CI<\/jats:styled-content>\n 95%=0.531 to 0.773,\n P<\/jats:italic>\n <.014), respectively. Multivariate logistic regression showed that\n sPAP<\/jats:styled-content>\n >70\u00a0mm Hg was the variable that most precisely correlated with right ventricular (\n RV<\/jats:styled-content>\n ) dysfunction as evidenced by\n TAPSE<\/jats:styled-content>\n <17\u00a0mm and\n RV<\/jats:styled-content>\n fractional shortening area (\n RVFSA<\/jats:styled-content>\n ) <35%. Left ventricular (\n LV<\/jats:styled-content>\n ) diastolic function was also significantly reduced in the group with severe\n PH<\/jats:styled-content>\n with mitral inflow E\/A ratio of 0.73\u00b10.23 vs 1.13\u00b10.42 in the group without severe\n PH<\/jats:styled-content>\n (\n sPAP<\/jats:styled-content>\n <70\u00a0mm Hg, (\n P<\/jats:italic>\n =.001). The pulmonary (Qp) to systemic (Qs) cardiac output ratio (3.09\u00b11.12) and right\u2010sided tissue Doppler S <9.5\u00a0cm\/s most accurately predicted a Tei index >0.55.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Larger size of\n ASD<\/jats:styled-content>\n using the\n QP<\/jats:styled-content>\n \/\n QS<\/jats:styled-content>\n ratio and increased right\u2010sided tricuspid E\/e\u2019 ratio correlated with severe\n PH<\/jats:styled-content>\n with a\n sPAP<\/jats:styled-content>\n of 70\u00a0mm Hg or more. Patients with severe\n PH<\/jats:styled-content>\n had more severe\n RV<\/jats:styled-content>\n dysfunction as evaluated by\n TAPSE<\/jats:styled-content>\n and\n RVFSA<\/jats:styled-content>\n in comparison to those with\n PH<\/jats:styled-content>\n <70\u00a0mm Hg.\n LV<\/jats:styled-content>\n diastolic function was also reduced in the severe\n PH<\/jats:styled-content>\n group.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/echo.13358","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T00:33:06Z","timestamp":1473121986000},"page":"1891-1896","source":"Crossref","is-referenced-by-count":10,"title":["Echocardiographic correlates of severe pulmonary hypertension in adult patients with ostium secundum atrial septal defect"],"prefix":"10.1111","volume":"33","author":[{"given":"Jorge","family":"Coss\u00edo\u2010Aranda","sequence":"first","affiliation":[{"name":"Outpatient Department National Institute of Cardiology Ignacio Ch\u00e1vez Mexico City 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