{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T07:13:48Z","timestamp":1757574828220},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Objectives<\/jats:title>To identify unique echocardiographic features that could be used to reliably predict LVEF<\/jats:styled-content> recovery upon resolution of sinus tachycardia in patients with cancer.<\/jats:p><\/jats:sec>Background<\/jats:title>Sinus tachycardia may be a manifestation of underlying cardiomyopathy or can lead to a reversible form of dilated cardiomyopathy known as tachycardia\u2010mediated cardiomyopathy. While distinguishing the two can be challenging, predicting recovery regardless of cause can be of significant clinical importance in the cancer population.<\/jats:p><\/jats:sec>Methods<\/jats:title>Results of echocardiograms performed were collected. Patients with a repeat echocardiogram within 6\u00a0months of the initial echocardiogram were included. Patients with structural heart disease, acute coronary syndrome, sepsis, and pericardial disease were excluded. A comparison between baseline echocardiogram and subsequent echocardiogram was made to determine whether specific echocardiographic parameters predicted LVEF<\/jats:styled-content> recovery. Two groups of patients were defined at the outset of the study. The recovered group was comprised of patients with reduced LVEF<\/jats:styled-content> in the setting of sinus tachycardia and normal LVEF<\/jats:styled-content> with resolution of tachycardia to normal sinus rhythm (NSR<\/jats:styled-content>). The unrecovered group was comprised of subjects with low LVEF<\/jats:styled-content> in the setting of both sinus tachycardia and NSR<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 40 patients were included in the study. LVEF<\/jats:styled-content> in the recovered group (n=18) was 42.8% with sinus tachycardia and increased to 58.3% with NSR<\/jats:styled-content>. Average LVEF<\/jats:styled-content> in the unrecovered group (n=22) was 35.1% with tachycardia and improved to 38.5% with NSR<\/jats:styled-content>. Medial TDI<\/jats:styled-content> (E\u2032) was significantly greater in the recovered group with both tachycardia (7.95\u00a0cm\/s versus 4.56\u00a0cm\/s, P<\/jats:italic><.001) and NSR<\/jats:styled-content> (8.11\u00a0cm\/s versus 5.13\u00a0cm\/s, P<\/jats:italic><.001). Similarly, lateral TDI<\/jats:styled-content> (E\u2032) was significantly greater in the recovered group than in the unrecovered group during tachycardia (8.97\u00a0cm\/s versus 5.13\u00a0cm\/s, P<\/jats:italic><.001) and NSR<\/jats:styled-content> (9.05\u00a0cm\/s versus 5.13\u00a0cm\/s, P<\/jats:italic><.001). Multivariable logistic regression analysis showed that medial TDI<\/jats:styled-content> >6.5\u00a0cm\/s (OR<\/jats:styled-content>=30.9, P<\/jats:italic>=.001) and lateral TDI<\/jats:styled-content> >7.8\u00a0cm\/s (OR<\/jats:styled-content>=52.5, P<\/jats:italic>=.002) are positively associated with the probability of LVEF<\/jats:styled-content> recovery.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In conclusion, TDI<\/jats:styled-content> (medial E\u2032>6.5\u00a0cm\/s; lateral E\u2032>7.8\u00a0cm\/s) appears to predict LVEF<\/jats:styled-content> recovery in patients with sinus tachycardia upon resolution of the tachycardia in patients with cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13372","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T12:16:47Z","timestamp":1477052207000},"page":"29-36","source":"Crossref","is-referenced-by-count":1,"title":["Predictors of left ventricular systolic function recovery in the setting of sinus tachycardia in patients with cancer"],"prefix":"10.1111","volume":"34","author":[{"given":"Saamir A.","family":"Hassan","sequence":"first","affiliation":[{"name":"Department of Cardiology Division of Medicine MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Wamique","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Department of Cardiology Division of Medicine MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoti","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Texas Health Science Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Texas Health Science Center Houston 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