{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T09:42:20Z","timestamp":1696412540254},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T00:00:00Z","timestamp":1477353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Program of Sustainability II (MEYS CR)","award":["LQ1605"],"award-info":[{"award-number":["LQ1605"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Noninvasive diagnosis of exercise\u2010induced elevation of left ventricular filling pressure is difficult and remains unsatisfactory. The aim of this study was to assess the accuracy of the ratio of early diastolic transmitral (E) to mitral annular (e\u2032) velocity and to determine new parameters or parameter combinations with the ability to predict exercise\u2010induced left atrial pressure (<jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content>) elevation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Eighty patients with paroxysmal atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) referred for catheter <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> ablation underwent simultaneous exercise echocardiography and direct invasive <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> measurements, as well as a resting and postexercise biomarker analysis. Exercise E\/e\u2032 \u22658.85 predicted exercise <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> \u226520\u00a0mm Hg with 61.5% sensitivity and 88.9% specificity (area under the curve [<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>], 0.76). Of all of the individual parameters tested, the best prediction was achieved with exercise E\/s\u2032 (s\u2032=peak systolic mitral annular velocity) \u22658.75 (sensitivity, 88.5%; specificity, 64.8%; positive predictive value, 54.8%; negative predictive value, 92.1%; <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>, 0.84). However, the combination of exercise E\/A (A = late diastolic transmitral flow velocity) \u22651.22 + exercise E\/e\u2032 \u22658.85 + exercise s\u2032\u226411.05\u00a0cm\/s provided the most precise prediction of exercise <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> elevation (sensitivity, 84.6%; specificity, 79.6%; positive predictive value, 66.7%; negative predictive value, 91.5%; <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>, 0.90).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Exercise E\/e\u2032, when used as a sole parameter, was not sufficiently reliable to predict exercise\u2010induced elevation of <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content>. The application of a multivariate\u2010adjusted combination of parameters appeared to be the preferable approach for the noninvasive prediction of exercise <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> elevation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13403","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T11:16:48Z","timestamp":1477394208000},"page":"78-86","source":"Crossref","is-referenced-by-count":1,"title":["Improvement in the prediction of exercise\u2010induced elevation of left ventricular filling pressure in patients with normal left ventricular ejection fraction"],"prefix":"10.1111","volume":"34","author":[{"given":"Jaroslav","family":"Meluzin","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases ICRC St. Anne's University Hospital  Brno Czech Republic"},{"name":"Department of Cardiovascular Diseases Faculty of Medicine Masaryk University  Brno Czech 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