{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T14:34:50Z","timestamp":1721658890463},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26860783"],"award-info":[{"award-number":["26860783"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Aims<\/jats:title>We studied how Doppler\u2010derived hemodynamic parameters in children change as the relative prosthetic mitral valve (PMV<\/jats:styled-content>) size decreases with somatic growth and evaluated the diagnostic utility of the parameters for detecting PMV<\/jats:styled-content> obstruction in children.<\/jats:p><\/jats:sec>Methods and Results<\/jats:title>We reviewed 26 echocardiographic examination results of 15 mechanical bileaflet PMV<\/jats:styled-content>s in 12 children. The median age at echocardiographic examination was 6.6 (0.6\u201318.1) years. The PMV<\/jats:styled-content> functioned normally in 24 examinations but was obstructed due to thrombosis in two cases. PMV<\/jats:styled-content> sizes ranged between 16 and 25\u00a0mm, which were standardized to body surface area (BSA<\/jats:styled-content>) at the examination with z\u2010score calculations. We assessed the peak E velocity, mean pressure gradient (PG<\/jats:styled-content>), and pressure half time (PHT<\/jats:styled-content>) of the transprosthetic flow, the velocity\u2013time integral (VTI<\/jats:styled-content>) ratio of the PMV<\/jats:styled-content> inflow to the left ventricular outflow, and the BSA<\/jats:styled-content>\u2010indexed effective orifice area (iEOA<\/jats:styled-content>) of the PMV<\/jats:styled-content> calculated with the continuity equation. Linear regression analysis revealed statistically significant correlations between all parameters of normally functioning PMV<\/jats:styled-content>s and the PMV<\/jats:styled-content> size z\u2010scores (Pearson correlation coefficients: peak E velocity, \u22120.68; mean PG<\/jats:styled-content>, \u22120.71; PHT<\/jats:styled-content>, \u22120.82; VTI<\/jats:styled-content> ratio, \u22120.76; iEOA<\/jats:styled-content>, 0.79). Compared with the predictive values derived from the regression equations, the VTI<\/jats:styled-content> ratio and iEOA<\/jats:styled-content> exceeded\u00a0\u00b1\u00a02 standard errors in both patients with obstructive PMVs.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>To assess PMV<\/jats:styled-content> function in children, Doppler\u2010derived hemodynamic parameters should be compared with their predictive values based on relative PMV<\/jats:styled-content> sizes. The deviation of the VTI<\/jats:styled-content> ratio and iEOA<\/jats:styled-content> from their predictive values may indicate prosthetic obstruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13406","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T05:43:36Z","timestamp":1478065416000},"page":"94-101","source":"Crossref","is-referenced-by-count":3,"title":["Echocardiographic assessment of prosthetic mitral valves in children"],"prefix":"10.1111","volume":"34","author":[{"given":"Taiyu","family":"Hayashi","sequence":"first","affiliation":[{"name":"Division of Cardiology National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Inuzuka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate School of Medicine University of Tokyo Tokyo 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