{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:11:04Z","timestamp":1776586264451,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T00:00:00Z","timestamp":1481241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Background<\/jats:title>Right ventricular systolic dysfunction (RVSD<\/jats:styled-content>) is a predictor of outcomes in dilated cardiomyopathy (DCM<\/jats:styled-content>) in adults, but little is known in children. Tricuspid annular plane systolic excursion (TAPSE<\/jats:styled-content>) has emerged as a reliable tool to assess RVSD<\/jats:styled-content>. We sought to determine the prevalence and prognostic significance of RVSD<\/jats:styled-content> using TAPSE<\/jats:styled-content> in children with DCM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>The first echocardiogram at the time of diagnosis with DCM<\/jats:styled-content> was analyzed to obtain left ventricular ejection fraction (LVEF<\/jats:styled-content>) and 2D TAPSE<\/jats:styled-content>. RVSD<\/jats:styled-content> was defined as TAPSE<\/jats:styled-content> age\u2010based z\u2010score \u2264\u22122. The association of a composite primary endpoint including death, mechanical support, or transplantation with RVSD<\/jats:styled-content> was analyzed using LVEF<\/jats:styled-content> and TAPSE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 96 patients, RVSD<\/jats:styled-content> was noted in 84 (88%). During a median follow\u2010up of 17.5\u00a0months (IQR<\/jats:styled-content> 1.4, 76.2), the primary endpoints were reached in 59%. There was a lower LVEF<\/jats:styled-content> in patients with RVSD<\/jats:styled-content> (P<\/jats:italic>=.016). Moderate or severe RVSD<\/jats:styled-content> showed a significant association with the composite primary endpoint (unadjusted OR<\/jats:styled-content> 2.7 [95% CI<\/jats:styled-content>: 1.15\u20136.33], P<\/jats:italic>=.023). Kaplan\u2010Meier analysis showed that the event\u2010free survival was significantly lower in patients with LVEF<\/jats:styled-content> \u226430% and TAPSE<\/jats:styled-content> z\u2010score \u2264\u22124.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Children with DCM<\/jats:styled-content> have a high prevalence of RVSD<\/jats:styled-content> based on reduced TAPSE<\/jats:styled-content>, and those with moderate or severe RVSD<\/jats:styled-content> have worse clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13416","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T09:37:21Z","timestamp":1481276241000},"page":"102-107","source":"Crossref","is-referenced-by-count":7,"title":["Tricuspid annular plane systolic excursion as a marker of right ventricular dysfunction in pediatric patients with dilated cardiomyopathy"],"prefix":"10.1111","volume":"34","author":[{"given":"Ericka 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