{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:22:17Z","timestamp":1769124137734,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T00:00:00Z","timestamp":1486944000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,2]]},"abstract":"Introduction<\/jats:title>Left ventricular (LV<\/jats:styled-content>) dysfunction is a major prognostic determinant in myotonic dystrophy type 1 (DM<\/jats:styled-content>1). Therefore, markers of early\u2010stage LV<\/jats:styled-content> impairment may be useful. The aim of this study was to evaluate 2D echocardiographic LV<\/jats:styled-content> strain in a cohort of DM<\/jats:styled-content>1 patients with preserved left ventricular ejection fraction (LVEF<\/jats:styled-content>) and to compare the results with matched controls.<\/jats:p><\/jats:sec>Methods<\/jats:title>This prospective single\u2010center study included 33 consecutive DM<\/jats:styled-content>1 patients between February 2014 and February 2015. Mean age was 38.2\u00b112.9\u00a0years, and 17 (52%) were males. Exclusion criteria were LVEF<\/jats:styled-content> <55%, QRS<\/jats:styled-content> >120\u00a0milliseconds, history of atrial fibrillation, and presence of a pacemaker with ventricular pacing. DM<\/jats:styled-content>1 patients were matched to healthy controls according to sex and age.<\/jats:p><\/jats:sec>Results<\/jats:title>DM<\/jats:styled-content>1 patients showed significant impairment of global longitudinal strain (GLS<\/jats:styled-content>) as compared to controls (\u221218.0\u00b11.9 vs \u221219.1\u00b12.4; P<\/jats:italic>=.03), characterized by a marked alteration at the apex (\u221220.0\u00b13.3 vs \u221222.7\u00b13.1; P<\/jats:italic><.001). DM<\/jats:styled-content>1 patients had also global radial strain impairment (20.0\u00b19.8 vs 27.5\u00b114.9; P<\/jats:italic>=.024) compared to controls while global circumferential strain was not statistically different between groups (P<\/jats:italic>=.94). Intra\u2010 and inter\u2010observer analysis showed good reproducibility of GLS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Despite preserved LVEF<\/jats:styled-content>, DM<\/jats:styled-content>1 patients exhibited significantly altered LV GLS<\/jats:styled-content>, particularly at the apex, as compared with controls. The detection of impaired myocardial deformation at early stages of the disease might help to screen high\u2010risk patients who need closer follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13426","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T05:26:53Z","timestamp":1486963613000},"page":"184-190","source":"Crossref","is-referenced-by-count":6,"title":["Apical left ventricular myocardial dysfunction is an early feature of cardiac involvement in myotonic dystrophy type 1"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9350-2437","authenticated-orcid":false,"given":"Rodrigue","family":"Garcia","sequence":"first","affiliation":[{"name":"Cardiology Service CHU Poitiers Poitiers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quentin","family":"Labarre","sequence":"additional","affiliation":[{"name":"Cardiology Service CHU Poitiers Poitiers 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