{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:58:31Z","timestamp":1788479911265,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,2]]},"abstract":"Background<\/jats:title>The aim of this study was to investigate left atrial (LA<\/jats:styled-content>) function and synchrony in paroxysmal atrial fibrillation (PAF<\/jats:styled-content>) patients using two\u2010dimensional speckle tracking echocardiography (STE<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010five PAF<\/jats:styled-content> patients and 30 healthy controls were enrolled. LA<\/jats:styled-content> peak ventricular systolic longitudinal strain (LAS<\/jats:sub><\/jats:styled-content>\u2010S<\/jats:sub>) and strain rate (LASR<\/jats:sub><\/jats:styled-content>\u2010S<\/jats:sub>) and left atrial longitudinal strain (LAS<\/jats:sub><\/jats:styled-content>\u2010A<\/jats:sub>) and strain rate (LASR<\/jats:sub><\/jats:styled-content>\u2010A<\/jats:sub>) during late diastole were determined using STE<\/jats:styled-content>, and the standard deviation of the time to peak (TPSD<\/jats:styled-content>) of the regional strains was calculated to quantify LA<\/jats:styled-content> dyssynchrony. TPSD<\/jats:styled-content> during ventricular systole and late diastole were named SD<\/jats:styled-content>s and SD<\/jats:styled-content>a, respectively.<\/jats:p><\/jats:sec>Results<\/jats:title>Left atrial peak longitudinal strain during ventricular systole (LAS<\/jats:sub><\/jats:styled-content>\u2010S<\/jats:sub>) (29.34\u00b18.57 vs 36.73\u00b16.13), LASR<\/jats:sub><\/jats:styled-content>\u2010S<\/jats:sub> (1.27\u00b10.311 vs 1.57\u00b10.25), LAS<\/jats:sub><\/jats:styled-content>\u2010A<\/jats:sub> (13.11\u00b14.91 vs 17.86\u00b13.57), and LASR<\/jats:sub><\/jats:styled-content>\u2010A<\/jats:sub> (\u22121.51\u00b10.58 vs \u22121.90\u00b10.30) were reduced in the PAF<\/jats:styled-content> group compared with the controls (P<\/jats:italic><.05 for all). SD<\/jats:styled-content>s (8.11\u00b13.00% vs 4.67\u00b11.48%) and SD<\/jats:styled-content>a (5.57\u00b12.26% vs 3.11\u00b11.13%) were greater in PAF<\/jats:styled-content> patients than in the controls (P<\/jats:italic><.05 for both). Furthermore, PAF<\/jats:styled-content> patients with normal LA<\/jats:styled-content> sizes exhibited lower LAS<\/jats:sub><\/jats:styled-content>\u2010S<\/jats:sub> (P<\/jats:italic><.05), LASR<\/jats:sub><\/jats:styled-content>\u2010S<\/jats:sub> (P<\/jats:italic><.05), LAS<\/jats:sub><\/jats:styled-content>\u2010A<\/jats:sub> (P<\/jats:italic><.05), and LASR<\/jats:sub><\/jats:styled-content>\u2010A<\/jats:sub> (P<\/jats:italic><.05) values and increased SD<\/jats:styled-content>s (P<\/jats:italic><.05) and SD<\/jats:styled-content>a (P<\/jats:italic><.05) values compared with the controls. Multivariate regression confirmed that SD<\/jats:styled-content>s and SD<\/jats:styled-content>a were powerful parameters for differentiating PAF<\/jats:styled-content> patients from controls (SD<\/jats:styled-content>s: sensitivity, 83%; specificity, 72%; SD<\/jats:styled-content>a: sensitivity, 81%; specificity, 76%).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Left atrial (LA<\/jats:styled-content>) dysfunction and dyssynchrony in PAF<\/jats:styled-content> patients can be detected with STE<\/jats:styled-content> even in the absence of LA<\/jats:styled-content> enlargement. STE<\/jats:styled-content>\u2010derived SD<\/jats:styled-content>s and SD<\/jats:styled-content>a were powerful parameters for identifying PAF<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13434","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T10:45:29Z","timestamp":1488192329000},"page":"176-183","source":"Crossref","is-referenced-by-count":38,"title":["Assessment of left atrial mechanical function and synchrony in paroxysmal atrial fibrillation with two\u2010dimensional speckle tracking echocardiography"],"prefix":"10.1111","volume":"34","author":[{"given":"Zhijuan","family":"Shang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Ultrasound The First Affiliated Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dechun","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound The First Affiliated Hospital of China Medical University Shenyang 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