{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:24:31Z","timestamp":1740137071654,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:00:00Z","timestamp":1484006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The mitral valve area (<jats:styled-content style=\"fixed-case\">MVA<\/jats:styled-content>) poorly reflects the hemodynamic status of (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>). In this study, we compared the <jats:styled-content style=\"fixed-case\">MVA<\/jats:styled-content> with mitral valve resistance (<jats:styled-content style=\"fixed-case\">MVR<\/jats:styled-content>) with regard to the determination of hemodynamic consequences of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> and the immediate outcomes of percutaneous balloon mitral valvuloplasty (<jats:styled-content style=\"fixed-case\">PBMV<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective study, 36 patients with severe rheumatic <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> with left ventricular ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>) &gt;50% were evaluated. They underwent transthoracic echocardiography (<jats:styled-content style=\"fixed-case\">TTE<\/jats:styled-content>) and catheterization. The <jats:styled-content style=\"fixed-case\">MVA<\/jats:styled-content> was measured by two\u2010dimensional planimetry and pressure half\u2010time (<jats:styled-content style=\"fixed-case\">PHT<\/jats:styled-content>), and the <jats:styled-content style=\"fixed-case\">MVR<\/jats:styled-content> was calculated using the equation: 1333\u00a0\u00d7\u00a0transmitral pressure gradient mean transmitral diastolic flow rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients\u2019 mean age was 47.8\u00b110.5\u00a0years. <jats:styled-content style=\"fixed-case\">MVR<\/jats:styled-content> \u2265140.6 dynes\u00b7s\/cm<jats:sup>5<\/jats:sup> detected systolic pulmonary arterial pressure (<jats:styled-content style=\"fixed-case\">sPAP<\/jats:styled-content>) &gt;55\u00a0mm Hg with a sensitivity of 100% and a specificity of 74%. The sensitivity and specificity of <jats:styled-content style=\"fixed-case\">MVA<\/jats:styled-content>&lt;0.75\u00a0cm<jats:sup>2<\/jats:sup> to discriminate elevated <jats:styled-content style=\"fixed-case\">sPAP<\/jats:styled-content> were 81% and 89%, respectively. <jats:styled-content style=\"fixed-case\">PHT<\/jats:styled-content> \u2265323.5\u00a0mseconds had a sensitivity of 78% and a specificity of 96% to detect an elevated <jats:styled-content style=\"fixed-case\">sPAP<\/jats:styled-content>. To predict a successful <jats:styled-content style=\"fixed-case\">PBMV<\/jats:styled-content>, preprocedural <jats:styled-content style=\"fixed-case\">MVR<\/jats:styled-content>\u00a0\u2265106.1 dynes\u00b7s\/cm<jats:sup>5<\/jats:sup> had a sensitivity of 100% and a specificity of 67% (area under the curve [<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>]=0.763; 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]=0.520\u20101.006; <jats:italic>P<\/jats:italic>=.034); preprocedural <jats:styled-content style=\"fixed-case\">MVA<\/jats:styled-content> &lt;0.95\u00a0cm<jats:sup>2<\/jats:sup> had a sensitivity of 78% and a specificity of 73% (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>=0.730; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>=0.503\u20100.956; <jats:italic>P<\/jats:italic>=.065); and preprocedural <jats:styled-content style=\"fixed-case\">PHT<\/jats:styled-content> \u2265210.5\u00a0mseconds had a sensitivity of 73% and a specificity of 78% (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>=0.707; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>=0.474\u20100.941; <jats:italic>P<\/jats:italic>=.095).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MVR<\/jats:styled-content> seems to be more accurate than <jats:styled-content style=\"fixed-case\">MVA<\/jats:styled-content> in determining the hemodynamic consequences of severe <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> as determined by <jats:styled-content style=\"fixed-case\">sPAP<\/jats:styled-content>. In addition, preprocedural MVR detected successful PBMVs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13448","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T06:23:11Z","timestamp":1484029391000},"page":"162-168","source":"Crossref","is-referenced-by-count":2,"title":["Mitral valve resistance determines hemodynamic consequences of severe rheumatic mitral stenosis and immediate outcomes of percutaneous valvuloplasty"],"prefix":"10.1111","volume":"34","author":[{"given":"Hamidreza","family":"Sanati","sequence":"first","affiliation":[{"name":"Cardiovascular Intervention Research Center Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Zolfaghari","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloufar","family":"Samiei","sequence":"additional","affiliation":[{"name":"Heart Valve Disease Research Center Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6804-4232","authenticated-orcid":false,"given":"Yousef","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Heart Valve Disease Research Center Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitra","family":"Chitsazan","sequence":"additional","affiliation":[{"name":"Heart Valve Disease Research Center Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences  Tehran 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