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Decrease in ventricular hypertrophy and improvement in ventricular function have been suggested as proof for efficacy. We report the cardiac response to ERT<\/jats:styled-content> of a child with IOPD<\/jats:styled-content> and severe hypertrophic cardiomyopathy. The myocardial hypertrophy resolved. Change in ejection fraction, however, was slow. We discuss the potential benefit of other parameters beyond ejection to assess cardiac function in IOPD<\/jats:styled-content>, including speckle tracking\u2010based strain.<\/jats:p>","DOI":"10.1111\/echo.13490","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T12:06:43Z","timestamp":1488888403000},"page":"621-624","source":"Crossref","is-referenced-by-count":8,"title":["Cardiac response to enzyme replacement therapy in infantile Pompe disease with severe hypertrophic cardiomyopathy"],"prefix":"10.1111","volume":"34","author":[{"given":"Sravani","family":"Avula","sequence":"first","affiliation":[{"name":"Department of Pediatrics (Cardiology) Louisiana State University Health Sciences Center New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuylinh M.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"School of Medicine Louisiana State University Health Sciences Center New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Marble","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Genetics) Louisiana State University Health Sciences Center New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3799-4689","authenticated-orcid":false,"given":"Christian","family":"Lilje","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Cardiology) Louisiana State University Health Sciences Center New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2014.12.004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2013.03.009"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-9-75"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv025"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.2.332"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2011.07.011"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.741157"},{"key":"e_1_2_5_9_1","volume-title":"Measurements in cardiology","author":"Sutton P","year":"1999"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2003.12.005"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951104002070"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.000175"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12947-015-0029-0"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.08.011"},{"key":"e_1_2_5_15_1","first-page":"304","article-title":"Over idiopatische hypertrophie van het hart","volume":"67","author":"Pompe JC","year":"1932","journal-title":"Ned Tijdshr Geneeskd"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.11.033"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e318183722f"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9179-2"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182142966"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-008-9267-3"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00577.2005"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067052"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-014-9707-6"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.13490","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.13490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:42:53Z","timestamp":1695505373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.13490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,7]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/echo.13490"],"URL":"https:\/\/doi.org\/10.1111\/echo.13490","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,7]]}}}