{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:02:16Z","timestamp":1768471336533,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Introduction and objectives<\/jats:title><jats:p>Cardiac manifestations in Fabry disease are mainly characterized by left ventricular hypertrophy (LVH). The aims of this study were (1) to describe the pattern of regional strain in patients with Fabry disease and (2) to assess whether this pattern may help differentiate patients with Fabry disease from patients with sarcomeric hypertrophic cardiomyopathy (HCM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010seven subjects were investigated: patients with Fabry disease (n=37; 57% with LVH), patients with HCM (n=21), and healthy controls (n=19). Global and segmental longitudinal and circumferential strain (CS) analyses were performed by two\u2010dimensional speckle strain imaging. Base\u2010to\u2010apex longitudinal and CS gradient, defined as the peak gradient difference between averaged basal and apical strain, was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Longitudinal strain gradient did not differ between controls and Fabry patients without hypertrophy (respectively: \u221210\u00b13.2 vs \u22128\u00b14.3, <jats:italic>P<\/jats:italic>=.41) or between the HCM group and Fabry patients with hypertrophy (respectively: \u22127.5\u00b14.5 vs \u22129\u00b14.5, <jats:italic>P<\/jats:italic>=.37). The CS gradient was lower in Fabry patients without hypertrophy compared to the controls (respectively: 1\u00b18 vs 14.2\u00b19.5, <jats:italic>P<\/jats:italic>&lt;.01), and lower in Fabry patients with hypertrophy compared to the HCM group (respectively: 0.5\u00b18 vs 6\u00b19, <jats:italic>P<\/jats:italic>&lt;.01). Base\u2010to\u2010apex CS gradient was lost in both Fabry groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Loss of base\u2010to\u2010apex CS gradient may be a specific left ventricular deformation pattern of Fabry cardiomyopathy in patients with and without LVH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13496","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T04:32:39Z","timestamp":1488515559000},"page":"504-510","source":"Crossref","is-referenced-by-count":35,"title":["Loss of base\u2010to\u2010apex circumferential strain gradient: A specific pattern of Fabry cardiomyopathy?"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4435-4401","authenticated-orcid":false,"given":"Fabien","family":"Labombarda","sequence":"first","affiliation":[{"name":"Department of Cardiology Caen CHU  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Saloux","sequence":"additional","affiliation":[{"name":"Department of Cardiology Caen CHU  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Milesi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Caen CHU  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Bienvenu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Caen CHU  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-30"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012428009627"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000139847.74101.03"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2007.03.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2008.00851.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-1425"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302353"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03625.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.023"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012447102358"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.02.046"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jer112"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000061952.27445.A0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.04.075"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000084500.72232.8D"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hco.0000136451.63329.17"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00231-3"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2012.01704.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000683"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2007.12.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1201"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0221-2"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.11.087"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.53"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.13496","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.13496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:42:40Z","timestamp":1695505360000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.13496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,2]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/echo.13496"],"URL":"https:\/\/doi.org\/10.1111\/echo.13496","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,2]]}}}