{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:42:36Z","timestamp":1787236956947,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,5]]},"abstract":"\n Backgrounds<\/jats:title>\n \n It's still unclear if different patterns of intraventricular flow dynamics may be detected in patients nonresponders to cardiac resynchronization therapy (\n CRT<\/jats:styled-content>\n ) as compared to responders ones. Aim of this study was to evaluate the characteristics of left ventricular (\n LV<\/jats:styled-content>\n ) flow dynamics 6\u2010months after\n CRT<\/jats:styled-content>\n to identify Echo\u2010particle imaging velocity (\n PIV<\/jats:styled-content>\n ) patterns were more frequently detected in nonresponders patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Thirty\u2010two patients with dilated cardiomyopathy, undergoing\n CRT<\/jats:styled-content>\n , were enrolled in this study. All patients underwent 2D and 3D echo and fluid dynamics assessment 6\u00a0months after\n CRT<\/jats:styled-content>\n , during active\n CRT<\/jats:styled-content>\n (\n CRT<\/jats:styled-content>\n \u2010\n ON<\/jats:styled-content>\n ) and during a temporarily discontinued state (\n CRT<\/jats:styled-content>\n \u2010\n OFF<\/jats:styled-content>\n ).\n LV<\/jats:styled-content>\n volumes systolic and diastolic volumes (\n LVESV<\/jats:styled-content>\n and\n LVEDV<\/jats:styled-content>\n ), ejection fraction (\n LVEF<\/jats:styled-content>\n ), global longitudinal strain (\n GLS<\/jats:styled-content>\n ), systolic dyssynchrony index (\n SDI<\/jats:styled-content>\n ), and several geometrical and functional Echo\u2010\n PIV<\/jats:styled-content>\n \u2010derived parameters were calculated. Patients were divided in two groups: \u201cresponders\u201d to\n CRT<\/jats:styled-content>\n (decrease in\n LVESV<\/jats:styled-content>\n >15% 6\u00a0months after\n CRT<\/jats:styled-content>\n ) and \u201cnonresponders.\u201d\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n During\n CRT<\/jats:styled-content>\n \u2010\n OFF<\/jats:styled-content>\n ,\n LVEF<\/jats:styled-content>\n ,\n GLS<\/jats:styled-content>\n were lower, while\n SDI<\/jats:styled-content>\n and\n LVESV<\/jats:styled-content>\n were higher in nonresponders group (\n P<\/jats:italic>\n =.030,\n P<\/jats:italic>\n =.051,\n P<\/jats:italic>\n =.035, and\n P<\/jats:italic>\n =.025, respectively). Energy dissipation, vortex area, and vorticity fluctuation were higher in \u201cnonresponders\u201d patients during\n CRT<\/jats:styled-content>\n \u2010\n OFF<\/jats:styled-content>\n (\n P<\/jats:italic>\n =.038,\n P<\/jats:italic>\n =.054, and\n P<\/jats:italic>\n =.035, respectively). During\n CRT<\/jats:styled-content>\n \u2010\n ON<\/jats:styled-content>\n , energy dissipation, vortex area, and vorticity fluctuation further increase in nonresponders patients (\n P<\/jats:italic>\n =.020,\n P<\/jats:italic>\n =.038, and\n P<\/jats:italic>\n =.030, respectively) with a concomitant worsening of\n SDI<\/jats:styled-content>\n (\n P<\/jats:italic>\n =.045).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our data show a significant worsening in flow\u2010derived parameters in\n CRT<\/jats:styled-content>\n \u201cnonresponders\u201d patients as compared with responders. Further larger longitudinal studies are necessary to assess whether these more chaotic intraventricular flow\u2010patterns may contribute to a persistent adverse remodeling observed in this subset of patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/echo.13518","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:26:00Z","timestamp":1490315160000},"page":"709-715","source":"Crossref","is-referenced-by-count":18,"title":["Significant increase of flow kinetic energy in \u201cnonresponders\u201d patients to cardiac resynchronization therapy"],"prefix":"10.1111","volume":"34","author":[{"given":"Sara","family":"Cimino","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Respiratory, Nephrology, Anestesiology and Geriatric Sciences Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dino","family":"Palombizio","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Respiratory, Nephrology, Anestesiology and Geriatric Sciences Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cicogna","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Respiratory, Nephrology, Anestesiology and Geriatric Sciences Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Cantisani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Respiratory, Nephrology, Anestesiology and Geriatric Sciences Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Reali","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Respiratory, Nephrology, Anestesiology and Geriatric Sciences Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Filomena","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Respiratory, Nephrology, Anestesiology and Geriatric Sciences Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Petronilli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Respiratory, Nephrology, Anestesiology and Geriatric Sciences Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Iacoboni","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Respiratory, Nephrology, Anestesiology and Geriatric Sciences Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-1797","authenticated-orcid":false,"given":"Luciano","family":"Agati","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Respiratory, Nephrology, Anestesiology and Geriatric Sciences Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039105.49749.6F"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht150"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.634444"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.01056.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.07.025"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.024"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.03.032"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.08.082"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743120"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600520103"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jet049"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(02)00005-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/35008075"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.95.108101"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.06.008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euromechflu.2012.03.014"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu106"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jer285"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.09.007"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs413"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes295"},{"key":"e_1_2_6_23_1","first-page":"10","article-title":"Can echocardiographic particle image velocimetry correctly detect motion patterns as they occur in blood inside heart chambers? A validation study using moving phantoms","volume":"6","author":"Prinz C","year":"2012","journal-title":"Cardiovasc Ultrasound"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000116765.43251.D7"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.09.021"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.01.372"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.04.004"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev137"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0158-5"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.08.078"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.13518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.13518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T03:44:30Z","timestamp":1696218270000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.13518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,23]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/echo.13518"],"URL":"https:\/\/doi.org\/10.1111\/echo.13518","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,23]]}}}